The Classification of Anxiety and Mood Disorders

焦虑和情绪障碍的分类

• 批准号: 8103462
• 负责人: Timothy A. Brown
• 金额: $ 5.98万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8103462
• 关键词: Accounting; Address; Alleles; Anxiety; Behavioral inhibition; Biological; Blood; Brain-Derived Neurotrophic Factor; Candidate Disease Gene; Cereals; Classification; Clinical; Cognitive; DSM-IV; DSM-V; Data; Dimensions; Disease; Disease susceptibility; Emotional; Emotional disorder; Environment; Equation; Evaluation; Frequencies; Genes; Genetic; Genotype; Growth; Hybrids; Individual Differences; Interview; Investigation; Life Stress; Longitudinal Studies; Measurement; Measures; Mediating; Mental disorders; Methods; Modeling; Mood Disorders; Neurotic Disorders; Outcome; Outpatients; Patient Self-Report; Patients; Phase; Psychometrics; Psychopathology; Saliva; Sampling; Series; Serotonin Receptor 5-HT2A; Severities; Specificity; Structural Models; Subgroup; Temperament; Time; Work; base; disease classification; disorder control; disorder subtype; follow-up; genetic association; indexing; longitudinal course; psychologic; psychosocial; response; theories; treatment effect

DESCRIPTION (provided by applicant): In the next phase of this longstanding project, we will expand our work on the cross-sectional and longitudinal structural relationships among genetically based dimensions of temperament (e.g., neuroticism), environmentally based dimensions of lower-order vulnerability, and the DSM-IV anxiety and mood disorder constructs. Over 1,750 subjects will be assessed with a variety of interview and self-report measures of temperament, vulnerability, and emotional disorder and will provide a blood or saliva sample for genotyping analysis. These data will be submitted to structural equation modeling (SEM) analyses to address a variety of specific aims including: (a) the first comprehensive evaluation of Barlow's triple vulnerability theory of emotional disorders; and (b) the differential relationships of selected candidate genes (e.g., 5-HTTLPR, BDNF, COMT, TPH) with dimensions of temperament and DSM-IV psychopathology. Longitudinal SEM analyses will examine a number of specific aims including: (a) the influence of genotypes in explaining the longitudinal course of DSM-IV disorder constructs and dimensions of vulnerability; (b) the extent to which genotypes interact with psychosocial treatment and life stress (GxE) to account for the course of temperament and psychopathology; (c) a temporal examination of Barlow's triple vulnerability theory (e.g., temporal directional relationships between temperament and psychological vulnerability in explaining course of DSM-IV disorders); and (d) a fine-grained analysis of the (bi)directional influence of temperament and DSM-UV psychopathology during the course of psychosocial treatment. A series of psychometric studies (e.g., item response theory, factor mixture modeling) will be conducted to address questions bearing on the classification of disorders in DSM-V (e.g., utility of dimensional vs. categorical classification; empirically based disorder subtyping; invariance of criteria sets across demographic subgroups). Key contributions of this work include: comprehensive evaluation of leading conceptual models of emotional disorders; explication of genetic factors that influence the severity and course of DMS-IV disorders, and refinement of the DSM-IV disorder and associated constructs that will inform DSM-V as well as biological studies by suggesting a more valid and robust set of disorder and vulnerability constructs on which to base such investigations.

描述（由申请人提供）：在这个长期项目的下一阶段中，我们将扩大基于基于遗传的气质（例如神经质）的横断面和纵向结构关系的工作，基于环境的下级脆弱性和DSM-IV焦虑症和情绪障碍结构的尺寸。超过1,750名受试者将通过各种访谈和气质，脆弱性和情绪障碍的措施进行评估，并将提供血液或唾液样本进行基因分型分析。这些数据将提交到结构方程建模（SEM）分析，以解决各种特定目标，包括：（a）对Barlow的三重脆弱性情绪障碍理论的首次全面评估； （b）选定候选基因（例如5-HTTLPR，BDNF，COMT，TPH）的差异关系具有气质和DSM-IV心理病理学的层面。纵向SEM分析将检查许多具体目的，包括：（a）基因型在解释DSM-IV疾病构建的纵向过程中的影响以及脆弱性的维度； （b）基因型与社会心理治疗和生命压力（GXE）相互作用的程度，以说明气质和心理病理学的过程； （c）对巴洛三重脆弱性理论的时间检查（例如，气质和心理脆弱性之间的时间定向在解释DSM-IV疾病过程中）； （d）对心态和DSM-UV心理病理学在心理社会治疗过程中的（BI）定向影响的细粒度分析。将进行一系列心理测量研究（例如，项目反应理论，因子混合模型），以解决有关DSM-V中疾病分类的问题（例如，维度分类与分类分类的效用；经验性疾病分类；基于经验性的疾病分类；基于范围跨域标准集的不变性。这项工作的主要贡献包括：对情绪障碍的主要概念模型的全面评估；阐明了影响DMS-IV疾病严重程度和过程的遗传因素，以及DSM-IV疾病和相关结构的完善，这些疾病将通过暗示更有效，更强大的障碍和脆弱性结构来为DSM-V以及生物学研究提供信息。