GENETIC EPIDEMIOLOGY OF ENDOMETRIOSIS

子宫内膜异位症的遗传流行病学

• 批准号: 7958815
• 负责人: CATHERINE ANNE MCCARTY
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958815
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Electronics; Endocrine; Enrollment; Family history of; Fertility; Fingers; Funding; Genotype; Grant; Institution; Interstitial Collagenase; Malignant Neoplasms; Medical; Medicine; Molecular; Operative Surgical Procedures; Outcome; Patient Self-Report; Physical activity; Primates; Printing; Quality of life; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Smoking History; Source; Time; Treatment Factor; United States National Institutes of Health; Wisconsin; Woman; cohort; endometriosis; genetic epidemiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The specific aims of this case-cohort research project are to: 1. Confirm the diagnosis of endometriosis in 937 women with electronic diagnoses of endometriosis who are enrolled in the Personalized Medicine Research Project. 2. Recruit additional women with surgically confirmed endometriosis into the PMRP cohort to reach a target of 1000 cases. 3. Administer validated endometriosis quality of life questionnaires5 to the women with confirmed endometriosis and document self-reported family history of endometriosis. 4. Quantify known risk factors (age, smoking history, physical activity, family history of endometriosis, endocrine factors), treatments (medical and surgical), and known outcomes (cancers, reduced fertility) in women with endometriosis. 5. Describe the genetic epidemiology of endometriosis in this cohort using the information collected in Aim 1 and a candidate SNP for endometriosis in the MMP1 gene6 that was genotyped in the PMRP molecular finger printing panel. This project is just getting started. We have no detailed or preliminary results at this time.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：该病例研究项目的具体目的是： 1。确认有937名具有子宫内膜异位症的电子诊断女性的子宫内膜异位症的诊断，这些妇女已入学，该子宫内膜异位症已入选个性化医学研究项目。 2。招募其他手术确认子宫内膜异位症的妇女进入PMRP队列，达到1000例靶标。 3。对已确认子宫内膜异位症的妇女进行经过验证的子宫内膜异位症调查问卷5，并记录自我报告的子宫内膜异位症家族史。 4。量化已知危险因素（年龄，吸烟史，体育活动，子宫内膜异位症，内分泌因素的家族史），治疗（医疗和外科手术）以及子宫内膜异位症女性的已知结局（癌症，降低的生育能力）。 5。使用AIM 1中收集的信息和在PMRP分子指定面板中基因分型的MMP1基因6中的子宫内膜异位症描述该队列中子宫内膜异位症的遗传流行病学。 这个项目才刚刚开始。 目前我们没有详细或初步结果。