PSD-95 REGULATION OF DOPAMINE RECEPTOR SIGNALING

PSD-95 多巴胺受体信号传导的调节

• 批准号: 7958339
• 负责人: Wei-Dong Yao
• 金额: $ 1.27万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958339
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Dendritic Spines; Dopamine Receptor; Funding; Goals; Grant; Head; Institution; Mediating; Molecular; Neurons; New England; Primates; Property; Receptor Signaling; Regulation; Research; Research Personnel; Resources; Scaffolding Protein; Source; Synapses; United States National Institutes of Health; Vertebral column; base; density; postsynaptic; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dopamine receptors are concentrated in dendritic spines of neurons, including the spine head and the postsynaptic density, where they are thought to control the excitability and synaptic properties of spines. The goal of this project is to investigate the molecular mechanisms mediating the regulation of dopamine receptor localization, trafficking, and function by PSD-95, a prototypic synaptic scaffolding protein within spines.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 多巴胺受体集中在神经元的树突状棘中，包括脊柱头和突触后密度，在那里它们被认为可以控制棘突的兴奋性和突触特性。该项目的目的是研究介导多巴胺受体定位，运输和功能PSD-95的分子机制，PSD-95是一种原型的突触脚手架蛋白质。