Mu Opioid Receptor in Addiction

Mu 阿片受体与成瘾关系

• 批准号: 7690774
• 负责人: Wade H Berrettini
• 金额: $ 84.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7690774
• 关键词: Mu; Opioid; Receptor; Addiction

DESCRIPTION (provided by applicant): Opioid dependence (OD) is a common, chronic, relapsing addiction with a substantial genetic component. Central to the neurobiology of OD is the mu opioid receptor (MOR), through which most of the rewarding effects of opioids are mediated. The goal of this developing center is to enhance our understanding of MOR in OD through mechanistic MOR research, mouse model studies and human OD genetic investigations. The Administrative Core (AC) will provide financial, logistical and organizational support to the developing center. The AC will serve three functions: (1) provide scientific leadership and evaluate center activities, (2), offer administrative support and (3) organize training and communication activities. The AC will include the Pis of the projects (Drs. Ferraro, Blendy, Levenson and Berrettini), as an executive committee. It will also include an Internal Advisory Board of three outstanding professors with expertise in areas vital to the developing center. These professors are Charles O'Brien, MD, PhD, Ted Abel, PhD and Ellen Unterwald, PhD. An External Advisory Board will also be constituted, after notification of funding, in accordance with the RFA. The executive committee, with the Internal and External Advisory Boards, will direct the scientific projects and cores, and will evaluate center progress. The AC will co-ordinate these efforts. In addition, the AC will provide support for the training initiatives of the developing center, including the introduction of an interdisciplinary course on opioids, accessible to graduate students and post-doctoral fellows at the University of Pennsylvania. Finally, the AC with organize, facilitate and provide logistic support for a course on OD, to be offered to graduate students, post-doctoral fellows and undergraduate students. PUBLIC HEALTH RELEVANCE: Heroin dependence is a significant public health problem, with more than 1 million US adults affected. This project will provide critical information regarding the function of the receptor to which heroin binds in the brain to produce its addicting effects. The results of these experiments should provide new avenues for development of treatment for heroin addiction, as well as new opportunities to provide chronic pain treatment with less liability to addiction.

描述（由申请人提供）：阿片类药物依赖性（OD）是一种常见的，慢性的，复发的成瘾，具有实质性的遗传成分。 OD神经生物学的核心是MU阿片受体（MOR），通过它介导了阿片类药物的大多数奖励作用。这个发展中心的目的是通过机械MOR研究，小鼠模型研究和人类OD遗传研究来增强我们对OD中MOR的理解。行政核心（AC）将为发展中心提供财务，后勤和组织支持。 AC将提供三个功能：（1）提供科学领导和评估中心活动，（2），提供行政支持以及（3）组织培训和交流活动。 AC将包括项目的PI（Ferraro博士，Blendy，Levenson和Berrettini），作为执行委员会。它还将包括一个内部顾问委员会，由三位杰出教授组成，这些教授在对发展中心至关重要的领域方面具有专业知识。这些教授是医学博士查尔斯·奥布莱恩（Charles O'Brien），博士学位，泰德·亚伯（Ted Abel）和艾伦·恩特瓦尔德（Ellen Unterwald）博士。根据RFA通知资金，还将构成外部顾问委员会。执行委员会拥有内部和外部咨询委员会，将指导科学项目和核心，并将评估中心的进步。 AC将协调这些努力。此外，AC还将为发展中心的培训计划提供支持，包括在宾夕法尼亚大学引入有关阿片类药物的跨学科课程和宾夕法尼亚大学的博士后研究员。最后，有组织，促进并为OD课程提供后勤支持的交流电，将为研究生，博士后研究员和本科生提供。 公共卫生相关性：海洛因依赖性是一个重大的公共卫生问题，有超过100万的美国成年人受到影响。该项目将提供有关海洛因在大脑中结合以产生其成瘾作用的受体功能的功能的关键信息。这些实验的结果应为开发海洛因成瘾治疗的新途径，以及提供慢性疼痛治疗的新机会，对成瘾的责任较少。