KINESIN INHIBITORS

驱动蛋白抑制剂

• 批准号: 8361577
• 负责人: TARUN M. KAPOOR
• 金额: $ 0.65万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361577
• 关键词: Binding; Cells; Complex; Funding; Grant; Kinesin; Mass Spectrum Analysis; Motor; National Center for Research Resources; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Work; cost; inhibitor/antagonist; macromolecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Kapoor Lab is working to develop a general inhibitor for kinesins-- one class of motor proteins in the cell. We have shown that some of her inhibitors bind to the kinesin Eg5 by observing the protein-inhibitor complex using native mass spectrometry readout.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 Kapoor Lab正在努力开发一种驱动蛋白的通用抑制剂 - 细胞中的一类运动蛋白。 我们已经表明，通过使用天然质谱读数观察蛋白质抑制剂复合物，她的某些抑制剂与驱动蛋白EG5结合。