CHEMICAL SYNTHESIS CORE FACILITY

化学合成核心设施

• 批准号: 8364932
• 负责人: ROBERT E. GAWLEY
• 金额: $ 11.91万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364932
• 关键词: Centers of Research Excellence; Commit; Core Facility; Dendrimers; Equipment; Faculty; Funding; Grant; Marine Toxins; Moon; National Center for Research Resources; Natural Products Chemistry; Organic Chemistry; Organic Synthesis; Pharmacologic Substance; Positioning Attribute; Preparation; Principal Investigator; Proteins; Quality Control; Research; Research Infrastructure; Resources; Roentgen Rays; Sesquiterpenes; Source; Structure; United States National Institutes of Health; Universities; chemical synthesis; cost; experience; instrumentation; interest; member; microwave electromagnetic radiation; protein structure function; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Chemical Synthesis Core Facility is directed by Robert Gawley, a new senior faculty member with extensive experience in synthetic organic chemistry and natural products chemistry, involving molecules such as sesquiterpenes, dendrimers, marine toxins, and chemosensors. A significant effort is being made in the COBRE Center to probe the interaction of small molecules with proteins, interactions which are responsible for the action of the vast majority of pharmaceuticals. These efforts require expertise in organic synthesis for the preparation of the small molecules, as well as in evaluating the interactions of the small molecules with proteins of interest. Equipment in the Synthesis Core facility includes eight Radley 12-vessel parallel synthesizers, a CEM Explorer Automated Microwave Synthesis Workstation, an Agilent GC-MS, and Bruker Avance 300 and 400 MHz NMR spectrometers. Of the $638,174 cost of the equipment in the core, $40,000 was provided by the COBRE grant, with the remainder coming from other grants and institutional funding. Dr Kwangyul Moon, an experienced synthetic organic chemist, is responsible for the synthesis and quality control of the compounds prepared in the core. The University has committed institutional funds to support permanent staff positions for Marvin Leister, Jerry Homesley, and K.Z. Shein, who maintain the instrumentation in the core. The University is also committing $210,000 for the purchase of a new small molecule X-ray diffractometer, which is needed to determine the structures of the molecules synthesized in the core.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 化学合成核心设施由罗伯特·高利（Robert Gawley）指导，罗伯特·高利（Robert Gawley）是一位新的高级教师，在合成有机化学和天然产物化学方面具有丰富的经验，涉及分子，例如替奎甲烯基，树枝状聚合物，海洋毒素和化学传感器。 在毛茸茸的中心正在努力探测小分子与蛋白质的相互作用，这些相互作用是导致绝大多数药物作用的相互作用。这些努力需要在制备小分子以及评估小分子与感兴趣蛋白质的相互作用方面的有机合成方面的专业知识。 合成核心设施中的设备包括八个Radley 12-Axel平行合成器，CEM Explorer自动化微波合成工作站，Agilent GC-MS以及Bruker Avance 300和400 MHz NMR光谱仪。 在核心的638,174美元的设备成本中，有40,000美元由Cobre Grant提供，其余的来自其他赠款和机构资金。 一位经验丰富的合成有机化学家Kwangyul Moon博士负责核心制备的化合物的合成和质量控制。 该大学已承诺机构资金，以支持Marvin Leister，Jerry Homesley和K.Z.的永久职员职位。 Shein，将仪器保持在核心中。 该大学还投入了21万美元，用于购买新的小分子X射线衍射仪，这是确定核心中合成的分子的结构所需的。