Community/Worker Exposures to Pathogens from Industrial Food Animal Production

社区/工人接触工业食用动物生产中的病原体

• 批准号: 8300691
• 负责人: Ellen K Silbergeld
• 金额: $ 36.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300691
• 关键词: Community; Worker; Exposures; Pathogens; Industrial

DESCRIPTION (provided by applicant): The overall goal of this project is to develop the evidence base for community and workers to respond to shared risks of pathogen exposures in rural areas where industrial food animal production operations are located. The overall hypothesis is that workers in food animal production and nearby communities share risks of exposure to and health impacts from exposure to community associated methicillin-resistant Staphyococcus aureus (CA-MRSA) of livestock origin, which is an emerging public health issue of major proportions in the US and for which there is growing evidence that industrial food animal production is a significant source especially for farmers, farm workers, and rural communities. The project will be carried out in partnership with representatives from community and national NGOs, labor unions, and other research groups. We will provide information on the following: (a) what is the prevalence of MRSA exposure in workers and communities in IFAP areas, (b) what are the workplace factors associated with risks of occupational exposure; (c) what are the pathways by which occupational exposures affect community health, including social networks and geospatial proximity, by which pathogen exposures may be transmitted across the work/environment nexus and among communities; (e) what populations are at special risk; and (f) what are the tractable barriers to risk reduction and effective actions by communities, public health officials, and government at all levels. The results of this research will be translated into public health actions through our partnership with communities, NGOs and labor and we will also develop an accessible program for evaluation to ensure policy effectiveness and empowerment of labor and community stakeholders in this process. The research component will involve a community based participatory health study to investigate risks of MRSA exposure among workers and community members, molecular typing of MRSA isolates, geospatial methods to investigate person-to-person contact and proximity factors, and multivariate regression analysis to identify other risk factors. The public health component will emphasize communication through multiple media, informational materials for community and labor use, analysis of existing policies in public health, environment, and agriculture. The evaluation component will cover both process and output to assess efficacy and uptake of the public health component, and to identify knowledge gaps that impede public health actions and community and labor empowerment. PUBLIC HEALTH RELEVANCE: This project links research with public health action through our focus on translatable research that will define points of intervention to reduce the emergence and spread of community acquired methicillin resistant Staphylococcus Aureus (CA-MRSA) among workers and communities. It s now recognized that much of the increasing prevalence of MRSA infections in the US is related to community sources and it is also increasingly clear that contact with animals, including swine and poultry, is an important and largely overlooked source of CA-MRSA. This project will carry out the first study to investigate these connections in the US and the first to study preventable risk factors that connect occupational and community populations in terms of exposures to livestock associated CA-MRSA.

描述（由申请人提供）：该项目的总体目标是为社区和工人建立证据基础，以应对所在的农村地区的病原体暴露风险。总体假设是，食用动物生产和附近社区的工人具有暴露于暴露于社区相关的耐甲氧西林的抗甲基甲基甲氧烷葡萄球菌（CA-MRSA）的风险，这是一个正在越来越多的证据，这是工业动物的生产，这是一个越来越多的养殖者。该项目将与社区和国家非政府组织，工会和其他研究小组的代表合作进行。我们将提供以下信息：（a）在IFAP地区工人和社区中MRSA暴露的患病率是多少，（b）与职业敞口风险有关的工作场所因素是什么？ （c）职业暴露会影响社区健康的途径，包括社交网络和地理空间接近性，通过这些病原体暴露在整个工作/环境之间以及社区之间传播的病原体暴露； （e）哪些人口有特殊风险； （f）各级社区，公共卫生官员和政府的风险降低和有效行动的可障碍障碍。这项研究的结果将通过与社区，非政府组织和劳工的合作伙伴关系转化为公共卫生行动，我们还将制定一项可访问的计划以进行评估，以确保在此过程中劳动力和社区利益相关者的政策有效性和授权。该研究组成部分将涉及一项基于社区的参与式健康研究，以调查工人和社区成员之间MRSA暴露的风险，MRSA分离株的分子键入，地理空间方法以调查人与人之间的接触和接近性因素以及多变量回归分析以识别其他风险因素。公共卫生部分将通过多种媒体，社区和劳动使用的信息材料，对公共卫生，环境和农业中现有政策的分析进行强调。评估部分将涵盖流程和产出，以评估公共卫生部分的功效和吸收，并确定阻碍公共卫生行动以及社区和劳动力授权的知识差距。 公共卫生相关性：该项目将研究与公共卫生行动联系起来，通过我们关注可翻译研究，该研究将定义干预点，以减少社区获得的甲氧西林金黄色葡萄球菌（CA-MRSA）在工人和社区中的出现和传播。现在已经认识到，美国MRSA感染的大部分患病率与社区来源有关，而且越来越明显的是，与包括猪和家禽在内的动物的接触是CA-MRSA的重要且在很大程度上被忽视的。该项目将进行第一项研究，以研究美国的这些联系，也是第一个研究可预防的风险因素，这些风险因素将职业和社区人口与牲畜相关的CA-MRSA接触。

项目成果

Genomic differences between nasal Staphylococcus aureus from hog slaughterhouse workers and their communities.

• DOI: 10.1371/journal.pone.0193820
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: You Y;Song L;Nonyane BAS;Price LB;Silbergeld EK
• 通讯作者: Silbergeld EK

Multidrug-resistant and methicillin-resistant Staphylococcus aureus (MRSA) in hog slaughter and processing plant workers and their community in North Carolina (USA).

• DOI: 10.1289/ehp.1306741
• 发表时间: 2014-05
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Neyra RC;Frisancho JA;Rinsky JL;Resnick C;Carroll KC;Rule AM;Ross T;You Y;Price LB;Silbergeld EK
• 通讯作者: Silbergeld EK

Exposure to pathogens among workers in a poultry slaughter and processing plant.

家禽屠宰和加工厂工人接触病原体。

• DOI: 10.1002/ajim.22594
• 发表时间: 2016
• 期刊: American journal of industrial medicine
• 影响因子: 3.5
• 作者: You,Yaqi;Leahy,Kimberly;Resnick,Carol;Howard,Tracy;Carroll,KarenColleen;Silbergeld,EllenKovner
• 通讯作者: Silbergeld,EllenKovner