NAPS2 Neuroimaging Core

NAPS2 神经影像核心

基本信息

批准号：
10674049
负责人：
KEJAL KANTARCI
金额：
$ 53.77万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10674049
关键词：
3-Dimensional Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Atrophic Brain Stem Brain imaging Cell Nucleus Clinical Clinical Data Clinical Research Collaborations Collection Communities Confidentiality of Patient Information Corpus striatum structure Cross-Sectional Studies Data Data Collection Data Set Dementia with Lewy Bodies Diffusion Diffusion Magnetic Resonance Imaging Disease Disease Progression Drug Delivery Systems Ensure Foundations Functional Magnetic Resonance Imaging Functional disorder Funding Future Genetic Goals Image Imaging Device Investigation Iron Laboratories Language Longitudinal Studies Magnetic Resonance Imaging Maintenance Maps Measurement Measures Methods Monitor Multiple System Atrophy Nerve Degeneration Neurodegenerative Disorders Office of Administrative Management Outcome Parasomnias Parkinson Disease Participant Patients Pattern Play Predisposition Process Protocols documentation Quality Control REM Sleep Behavior Disorder Radionuclide Imaging Reproducibility Research Research Personnel Resolution Resources Rest Role Scanning Site Standardization Substantia nigra structure Symptoms Techniques Testing Thick Time United States National Institutes of Health Work basal forebrain biomarker identification candidate marker cerebral atrophy clinical care data management data sharing dopamine system experience genetic information high risk image processing imaging modality imaging study innovation interest locus ceruleus structure longitudinal analysis multimodality neuroimaging neuroimaging marker neuromelanin neuroprotection pars compacta programs progression marker prospective single photon emission computed tomography sound synucleinopathy targeted biomarker targeted treatment trial design uptake web site

项目摘要

ABSTRACT: NAPS2 NEUROIMAGING CORE The Neuroimaging Core of the North American Prodromal Synucleinopathy Consortium on RBD, Stage 2 (NAPS2) will ensure that state-of-the-art techniques are applied and that innovative analytic techniques are used. The Neuroimaging Core will be directed by leaders in brain imaging in neurodegenerative diseases with extensive experience supporting the imaging needs of multi-site projects. Many of the Core leaders have collaborated with NAPS investigators on prior research in RBD and synucleinopathies. The prior experience and collaborations within the Neuroimaging Core team will ensure a smooth transition of imaging support for NAPS2. Prior imaging studies of RBD are few and have generally been small, retrospective, or single-site investigations. We provide preliminary data to support all of the imaging modalities that will be utilized in the protocol and demonstrate the soundness of the methods proposed. We will prospectively collect and evaluate multimodal MRI and DaTscan imaging data in over 300 participants with RBD longitudinally, at two time points, with innovative methods to support the Project and advance the field. There are several innovative aspects of this Core, including the use of: 1) multi-shell and multi-band imaging acquisition protocols for collection of high resolution dMRI and rs-fMRI data in reasonable acquisition time, harmonized across multiple sites, 2) quantification of iron load with multi-echo gradient echo (GRE) MRI using quantitative susceptibility mapping and R2* relaxometry, 3) quantification of neuromelanin volume in locus coeruleus and substantia nigra pars compacta using a magnetization transfer contrast neuromelanin-sensitive MRI (NM-MRI) approach with automated image processing and high reproducibility, and 4) DaTscan quantitative analysis using semi-automated processing to provide standardized and harmonized region-to-background and z-score data. The Neuroimaging Core aims are to: 1) establish and maintain harmonized MRI and DaTscan SPECT acquisition protocols at the participating sites, 2) operate a standardized quality control program for MRI and DaTscan, including ongoing image quality monitoring, rating and maintenance, and 3) supply processed cross-sectional and longitudinal data on serial MRIs and DaTscans for the Project focused on predicting phenoconversion, and share these data with the research community. This latter aim includes providing cross-sectional and longitudinal data to the Laboratory of Neuroimaging (LONI) for sharing with outside investigators. All images will be anonymized and directly downloadable from the LONI website. Language will be developed on the NAPS2 and LONI websites to guide outside investigators interested in these data. This clinical dataset will be freely downloadable along with the images for researchers who do not require genetic information for their analyses.

摘要：NAPS2 神经影像核心北美前驱突触核蛋白病联盟 RBD 的神经影像核心，第二阶段（NAPS2）将确保应用最先进的技术以及创新的分析使用技术。神经影像核心将由脑成像领域的领导者指导神经退行性疾病领域拥有丰富的经验，支持多站点项目的成像需求。许多核心领导者曾与 NAPS 研究人员合作开展 RBD 和突触核蛋白病。神经影像核心团队之前的经验和合作将确保 NAPS2 成像支持的平滑过渡。先前对 RBD 的影像学研究很少，并且通常是小型、回顾性或单点调查。我们提供初步数据来支持所有将在协议中使用并证明方法合理性的成像方式建议的。我们将前瞻性地收集和评估 300 多个多模态 MRI 和 DaTscan 成像数据参与者在两个时间点纵向采用 RBD，采用创新方法来支持该项目和推进该领域。该核心有几个创新方面，包括使用：1) 多壳和多波段成像采集协议，用于以合理的方式收集高分辨率 dMRI 和 rs-fMRI 数据采集时间，跨多个站点协调，2) 使用多回波梯度回波量化铁负荷 (GRE) MRI 使用定量磁敏图和 R2* 松弛测量法，3) 神经黑色素的定量使用磁化传递对比测量蓝斑和黑质致密部的体积神经黑色素敏感 MRI (NM-MRI) 方法具有自动图像处理和高重复性， 4) 使用半自动处理的 DaTscan 定量分析，提供标准化和协调区域到背景和 z 分数数据。神经影像学核心目标是：1) 建立和在参与站点维护统一的 MRI 和 DaTscan SPECT 采集协议，2) 运行 MRI 和 DaTscan 的标准化质量控制程序，包括持续的图像质量监控、评级和维护，以及 3) 提供经过处理的连续 MRI 和 DaTscan 的横截面和纵向数据该项目专注于预测表型转化，并与研究界分享这些数据。后一个目标包括向神经影像实验室提供横截面和纵向数据（LONI）与外部调查人员共享。所有图像都将被匿名化并可直接从洛尼网站。将在 NAPS2 和 LONI 网站上开发语言以指导外界研究人员对这些数据感兴趣。该临床数据集将与图像一起免费下载适用于不需要遗传信息进行分析的研究人员。