Adolescents with Substance and Conduct Problems: Imaging Callous-Unemotionality

有物质和品行问题的青少年：想象冷酷无情

• 批准号: 8295350
• 负责人: JOSEPH T SAKAI
• 金额: $ 34.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-15 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8295350
• 关键词: Adolescence; Adolescent; Adult; Age; Altruism; Amygdaloid structure; Anatomy; Anterior; Behavior; Behavior Disorders; Biological; Brain; Childhood; Code; Conduct Disorder; Data; Decision Making; Development; Diagnostic; Diagnostic and Statistical Manual; Disease; Disinhibition; Early treatment; Environment; Etiology; Functional Magnetic Resonance Imaging; Future; Genetic Predisposition to Disease; Image; Imaging problem; Individual; Insula of Reil; Interview; Lead; Link; Literature; Magnetic Resonance Imaging; Male Adolescents; Measures; Morbidity - disease rate; Neurobiology; Nucleus Accumbens; Outcome; Patients; Performance; Play; Prevention; Problem behavior; Public Health; Race; Recruitment Activity; Refractory; Research Personnel; Resistance; Severities; Signal Transduction; Staging; Structure; Subgroup; Substance Addiction; Substance Use Disorder; System; Testing; Thick; Treatment outcome; Work; Youth; angular gyrus; anti social; base; callous unemotional trait; cost; design; externalizing behavior; gray matter; improved; male; mortality; neuroimaging; novel; relating to nervous system; residence; trait; young adult

DESCRIPTION (provided by applicant): This proposal, submitted by an early stage investigator, seeks four years of R01 support to conduct an MRI study of adolescent patients with serious substance and conduct problems and adolescent controls. This proposal seeks to identify the neural correlates (both functional and structural) of callous-unemotionality (CU). CU is identifiable in childhood and adolescence, is a relatively stable trait into adulthood, and is linked with persistent antisocial behavior problems and substance dependence; individuals with CU, antisocial behavior problems and substance use disorders appear more resistant to treatment. This proposal will also allow searching for neural correlates of subtypes of adolescent-onset substance dependence. We will recruit, complete extensive diagnostic interviews and image subjects while they play the AlAn's game. That game, which was designed for use in the MRI environment, has demonstrated a strong relationship with CU trait scores in our out-of-magnet pilot testing. PUBLIC HEALTH RELEVANCE: Substance use disorders and antisocial behavior are major public health problems, are linked to serious morbidity and high mortality and have a partial genetic etiology. Callous-unemotional traits are identifiable in childhood and adolescents, are relatively stable into young adulthood and predict future and persistent antisocial behavior and substance problems. The current study proposes a search for neurobiological correlates callous-unemotionality and subtypes of adolescent-onset substance dependence. Better understanding the biological etiology of these disorders may lead to better prevention or treatment approaches.

描述（由申请人提供）：该提案由早期研究人员提交，寻求R01的四年支持，以对具有严重物质并进行问题的青春期患者进行MRI研究。该提案旨在确定Callous-Ounosionation（CU）的神经相关性（功能和结构）。 Cu在童年时期和青春期都可以识别，是成年期相对稳定的特征，与持续的反社会行为问题和物质依赖性有关。具有CU，反社会行为问题和药物使用障碍的人似乎对治疗更具抵抗力。该建议还将允许搜索青少年发作物质依赖性亚型的神经相关性。我们将在玩Alan的游戏时招募，完成广泛的诊断访谈和图像主题。该游戏是为在MRI环境中使用的，在我们的魔术师外试验测试中与CU特质分数有着牢固的关系。 公共卫生相关性：药物使用障碍和反社会行为是主要的公共卫生问题，与严重的发病率和高死亡率有关，并且具有部分遗传病因。老茧的情感特征在童年时期是可以识别的，青少年在成年中相对稳定，并预测未来和持续的反社会行为和物质问题。当前的研究提出了对神经生物学相关性的搜索，该相关性是青少年发作的物质依赖性的血腥感染性和亚型。更好地了解这些疾病的生物学病因可能会导致更好的预防或治疗方法。