MECHANISMS OF ADAPTATION IN HUMAN SHORT BOWEL SYNDROME

人类短肠综合症的适应机制

• 批准号: 7603650
• 负责人: Thomas R Ziegler
• 金额: $ 0.31万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603650
• 关键词: Antibodies; Apoptosis; Biological Markers; Cell Proliferation; Citrulline; Computer Retrieval of Information on Scientific Projects Database; Enterocytes; Exhibits; Flagellin; Funding; Grant; Growth; Human; Institution; Mucous Membrane; Nutrient; Plasma; Research; Research Personnel; Residual state; Resources; Serum; Short Bowel Syndrome; Small Intestines; Source; United States National Institutes of Health; absorption; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to determine after massive SBR whether the residual small bowel and colonic mucosa exhibits adaptive growth, with concomitantly improved nutrient absorption and gut barrier function. In addition, the study aims to determine potential mechanisms of early gut adaptation in human SBS by evaluating changes in mucosal cell proliferation and apoptosis and expression of key molecules known to regulate nutrient transport/absorption and gut barrier function and to evaluate the utility of plasma citrulline concentrations and serum flagellin antibody titers as biomarkers for human enterocyte absorptive capacity and gut barrier function, respectively.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是在大规模的SBR之后确定残留的小肠和结肠粘膜是否表现出适应性生长，并随之改善了营养吸收和肠道屏障功能。 此外，该研究旨在通过评估粘膜细胞增殖和凋亡的变化以及已知的关键分子的表达来确定人类SBS早期肠道适应的潜在机制功能分别。