ACTG A5157

ACTG A5157

• 批准号: 7603671
• 负责人: Jeffrey Lennox
• 金额: $ 0.17万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603671
• 关键词: AIDS clinical trial group; Adipose tissue; Biopsy; Computer Retrieval of Information on Scientific Projects Database; Dideoxynucleosides; Distal; Dose; Funding; Grant; Institution; Label; Levocarnitine Acetyl; Nerve Fibers; Pain; Peripheral Nervous System Diseases; Pilot Projects; Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Week; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A multicenter, open-label, 24-week pilot study with dose escalation of acetyl-L-carnitine (ALC) for the treatment of distal symmetric peripheral neuropathy (DSPN) associated with dideoxynucleosides in HIV-infected subjects. Gracely pain scale assessments and safety information will be obtained every 6 weeks. An intraepidermal nerve-fiber and subcutaneous adipose tissue biopsy will be obtained at baseline and 24 weeks.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 一项多中心，开放标签的24周初步研究，乙酰基-L-肉碱（ALC）剂量升级，用于治疗与HIV受试者中与二乙基核苷有关的远端对称外周神经病（DSPN）。 每6周将获得一次性疼痛评估和安全信息。 在基线和24周时，将获得皮肤内神经纤维和皮下脂肪组织活检。