Impact of Cognitive Reserve on Memory Functioning in Multiple Sclerosis

认知储备对多发性硬化症记忆功能的影响

• 批准号: 7643501
• 负责人: James Francis Sumowski
• 金额: $ 7.84万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-10 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7643501
• 关键词: Accounting; Address; Alzheimer' s Disease; Basic Science; Biological Neural Networks; Brain; Brain Pathology; Budgets; Cerebrum; Clinical; Cognitive; Competence; Data; Disabled Persons; Disease; Early treatment; Employment; Etiology; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Grant; Health; Human; Impaired cognition; Individual; K-Series Research Career Programs; Knowledge; Laboratories; Learning; Life Experience; Literature; Magnetic Resonance Imaging; Memory; Memory impairment; Mentors; Multiple Sclerosis; Neurobehavioral Manifestations; Neurologic; Neuronal Plasticity; Neurorehabilitation; Parietal; Pathology; Patients; Pattern; Persons; Phase; Population; Preparation; Principal Investigator; Process; Productivity; Publishing; Quality of life; Rehabilitation Research; Rehabilitation therapy; Relative (related person); Research; Research Personnel; Research Project Grants; Research Training; Risk; Risk Factors; Role; Short-Term Memory; Site; Source; Staging; Sum; Synapses; Technology; Training; Verbal Learning; base; career; cerebral atrophy; chronic neurologic disease; cognitive function; cognitive rehabilitation; cognitive reserve; coping; data acquisition; improved; innovation; innovative technologies; interest; middle age; neuropsychological; novel; outcome forecast; patient oriented; patient oriented research; programs; public health relevance; relating to nervous system; skills; theories; tool; treatment planning

DESCRIPTION (provided by applicant): As indicated by NCMRR, the primary goal of patient-oriented research is to develop the "scientific knowledge necessary to enhance the health, productivity, independence, and quality-of-life of people with disabilities." Multiple sclerosis is a prevalent and chronic neurologic disease associated with memory dysfunction and cerebral inefficiency, which encumber productivity, limit independence, and frequently diminish the quality of life among many young and middle aged persons with MS. Despite this, the etiology of memory dysfunction in MS is very poorly explained by brain pathology alone, perhaps due to yet undiscovered protective factors. This CDA project will investigate the role of cognitive reserve in protecting persons with MS from disease- related memory dysfunction and cerebral inefficiency. Cognitive reserve theory proposes that enriching life experiences (such as educational attainment) increase the capacity and efficiency of neural networks. When cerebral functioning is challenged by neurologic disease, individuals with more cognitive reserve are better able to cope with the increased cognitive demands. This has been demonstrated in Alzheimer's Disease and other neurologic conditions, but the current proposal is the first to directly investigate cognitive reserve in MS. During the mentored phase of this grant, I will investigate whether cognitive reserve protects persons with MS from the deleterious effects of brain pathology on learning and memory. My primary training aim is to develop competence in fMRI. Combined with the rich research training at KMRREC, fMRI training will enable me to investigate the protective role of cognitive reserve on cerebral efficiency in MS, and prepare me for a career as an independent patient-oriented researcher utilizing this innovative technology. These projects represent the first steps in my plan to pursue a more comprehensive research program directed toward (1) identifying sources of protective cognitive reserve and (2) using these sources as a means to reduce the negative impact of neurologic disease on quality of life for persons with MS in particular, and neurologic patients in general. This Career Development Award is a necessary and essential step in my plans to become an independent patient-oriented researcher. PUBLIC HEALTH RELEVANCE: Demonstration of the protective role of cognitive reserve in MS will fill wide gaps in the MS and cognitive reserve literatures. Identification of low cognitive reserve as a risk factor will improve prognoses of cognitive dysfunction, thereby promoting early intervention cognitive rehabilitation. I will pursue a program of research to identify other modifiable sources of reserve, which can then be utilized for preventative neurorehabilitation.

描述（由申请人提供）：如NCMRR所示，以患者为导向的研究的主要目标是开发“增强残疾人的健康，生产力，独立性和生活质量生活所必需的科学知识”。多发性硬化症是一种与记忆功能障碍和脑效率低下相关的普遍和慢性神经系统疾病，它可以抵制生产力，限制独立性，并且经常降低许多具有MS的年轻人和中年人的生活质量。尽管如此，仅仅是由于尚未发现的保护因素而导致的，MS中记忆功能障碍的病因却很难解释。该CDA项目将调查认知储备在保护MS免受疾病相关记忆功能障碍和大脑效率低下的人中的作用。认知储备理论提出，丰富生活经验（例如教育程度）可以提高神经网络的能力和效率。当脑功能受到神经系统疾病的挑战时，认知储备更高的个体可以更好地应对认知需求的增加。这在阿尔茨海默氏病和其他神经系统疾病中已经证明了这一点，但是当前的提案是第一个直接研究MS认知储备的建议。在这笔赠款的指导阶段，我将调查认知储备是否保护MS的人免受脑病理学对学习和记忆的有害影响。我的主要培训目的是发展功能磁共振成像的能力。结合了KMRREC的丰富研究培训，fMRI培训将使我能够调查认知储备对MS脑效率的保护作用，并为我的职业做好准备，以实现这一创新技术的独立面向患者的研究人员。这些项目是我计划中的第一步，该计划是针对（1）识别保护性认知储备的来源的更全面的研究计划，以及（2）使用这些来源作为减少神经系统疾病对MS尤其是MS的生活质量的负面影响的手段，通常是神经学患者。这项职业发展奖是我成为独立面向患者的研究人员的计划中必不可少的一步。 公共卫生相关性：表明认知储备在MS中的保护作用将填补MS和认知储备文献中的巨大空白。将低认知储备作为危险因素的识别将改善认知功能障碍的预后，从而促进早期干预认知康复。我将进行一项研究计划，以识别其他可修改的储备来源，然后可以将其用于预防性神经居住。

项目成果

Retrieval practice: a simple strategy for improving memory after traumatic brain injury.

检索练习：脑外伤后改善记忆的简单策略。

• DOI: 10.1017/s1355617710001128
• 发表时间: 2010
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Sumowski,JamesF;Wood,HaliG;Chiaravalloti,Nancy;Wylie,GlennR;Lengenfelder,Jeannie;DeLuca,John
• 通讯作者: DeLuca,John

Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve.

• DOI: 10.1093/brain/awp307
• 发表时间: 2010-02
• 期刊: Brain : a journal of neurology
• 作者: Sumowski JF;Wylie GR;Deluca J;Chiaravalloti N
• 通讯作者: Chiaravalloti N

Functional magnetic resonance imaging movers and shakers: does subject-movement cause sampling bias?

• DOI: 10.1002/hbm.22150
• 发表时间: 2014-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Wylie, Glenn R.;Genova, Helen;DeLuca, John;Chiaravalloti, Nancy;Sumowski, James F.
• 通讯作者: Sumowski, James F.

Brain reserve against physical disability progression over 5 years in multiple sclerosis.

多发性硬化症患者 5 年内针对身体残疾进展的大脑储备。

• DOI: 10.1212/wnl.0000000000002702
• 发表时间: 2016
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Sumowski,JamesF;Rocca,MariaA;Leavitt,VictoriaM;Meani,Alessandro;Mesaros,Sarlota;Drulovic,Jelena;Preziosa,Paolo;Habeck,ChristianG;Filippi,Massimo
• 通讯作者: Filippi,Massimo