Obesity-related Host Susceptibility Factors for Asthma in Women

女性哮喘与肥胖相关的宿主易感性因素

• 批准号: 7739002
• 负责人: AKSHAY SOOD
• 金额: $ 18.15万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739002
• 关键词: Affect; Anti-Inflammatory Agents; Anti-inflammatory; Area; Asthma; Biochemical; Body mass index; Clinical; Complex; Cross-Sectional Studies; Deposition; Development Plans; Doctor of Philosophy; Dual-Energy X-Ray Absorptiometry; Educational Curriculum; Educational workshop; Epidemiology; Equilibrium; Exhalation; Fatty acid glycerol esters; Fellowship; Funding; Genetic; Goals; Hormonal; Immune; Inflammation; Inflammatory; Instruction; Leadership; Leptin; Measures; Mechanics; Mentors; Mentorship; National Heart, Lung, and Blood Institute; New Mexico; Obesity; Outcome Measure; Pathogenesis; Pathway interactions; Peripheral; Phase; Phenotype; Physiological; Population Study; Predisposition; Premenopause; Principal Investigator; Quail; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Serum; Sputum; Stress; Structure; Symptoms; Training; Translational Research; Universities; Variant; Weight; Woman; abstracting; adipokines; adiponectin; airway inflammation; asthma prevention; base; career; career development; cohort; design; experience; interest; mast cell; methacholine; oxidant stress; patient oriented research; programs; prospective; response

DESCRIPTION (provided by applicant): The candidate is a clinically trained pulmonologist who has recently embarked on a career in translational research at the University of New Mexico. The candidate's long-term objective is to establish a fully funded, independent research career and provide national leadership in the field of asthma epidemiology. He is interested in investigating the role of obesity-related host susceptibility factors for asthma in women. Interest in this field developed during routine clinical observations that prompted the candidate to re-emphasize his past training in epidemiology during his fellowship. The proposed career development plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience in association with a structured didactic curriculum in specific competencies related to the candidate's project and career goals. Under the mentorship of senior investigators, Marianne Benwick, Ph.D., Mark Schuyler, MD and Clifford Quails, Ph.D., the candidate will investigate whether central adiposity and the pro-inflammatory balance of serum adipokines affect specific physiologic and pathophysiologic sub- phenotypes of asthma in pre-menopausal women with asthma. Specific Aim 1 will examine the association between central adiposity and ainway outcome measures, using a cross-sectional study of 200 pre- menopausal women with methacholine challenge-confirmed asthma. Airway outcome measures include dynamic hyperinflation following methacholine bronchoprovocation and markers of eosinophilic inflammation and oxidant stress in induced sputum and exhaled breath condensate respectively. Specific Aim 2 involves a nested prospective cohort of 19 obese and 19 normal weight eumenorrheic women with asthma. The effect of diurnal and menstrual phase-related physiological variation in serum leptin to adiponectin ratio on ainn/ay outcome measures will be studied. This area of research is considered a high priority at the 2004 workshop on 'Obesity and Asthma' by the NHLBI. This study may help define the mechanistic basis forthe relationship between obesity and asthma, which in turn may make possible newer ways of treatment and prevention of asthma. RELEVANCE (See instructions): This study may help define the mechanistic basis for the relationship between asthma and obesity-related host susceptibility factors in women, which in turn may make possible newer ways of treatment and prevention of asthma. This study will also provide mentored training to a clinician for a patient-oriented research career. (End of Abstract)

描述（由申请人提供）：候选人是一名受临床训练的肺科医生，最近从事新墨西哥大学转化研究职业。候选人的长期目标是建立完全资助的独立研究职业，并在哮喘流行病学领域提供国家领导。他有兴趣调查与肥胖相关的宿主易感因素在女性中的作用。对这一领域的兴趣在常规临床观察期间发展，这促使候选人重新强调了他在研究金期间对流行病学的过去培训。拟议的职业发展计划纳入了一项多学科计划，旨在提供与候选人项目和职业目标相关的特定能力的结构化教学课程，以提供激烈，受到患者的研究经验。在高级研究人员的指导下，Marianne Benwick博士，Mark Schuyler，医学博士和Clifford Quails博士，候选人将调查中心肥胖和血清脂肪因子的促炎平衡是否影响特定的生理生理学和病理生理学和病理生理学的亚themate型，伴随着妇女的妇女，妇女与妇女的妇女有关。具体目标1将使用对200例绝经前妇女与甲基苯胺挑战确认的哮喘进行的横断面研究，研究中央肥胖与AINWay结局指标之间的关联。气道结局措施包括分别在诱导的痰液和呼出的呼吸凝结物中，甲氧氨基支气管固定后的动态过度充气和嗜酸性炎症的标记和嗜酸性炎症的标记和氧化应激。特定的目标2涉及19例肥胖的前瞻性队列和19例正常体重Eumenorrheic妇女患有哮喘。将研究血清瘦素与脂联素比率对AINN/AY结果指标的昼夜和月相关生理变异的影响。 NHLBI在2004年关于“肥胖和哮喘”的研讨会上，这一研究领域被认为是高度重视。这项研究可能有助于定义肥胖与哮喘之间关系的机理基础，这反过来又可能使哮喘的治疗和预防方法可能更新。相关性（请参阅说明）：本研究可能有助于定义哮喘与肥胖相关的宿主易感因素之间关系的机械基础，而女性可能会使哮喘的治疗和预防哮喘的较新方法。这项研究还将为临床医生提供指导的培训，从而以患者为导向的研究职业。 （抽象的结尾）