Large-Scale Vaccinia Virus-Derived CTL Epitope Discovery

大规模痘苗病毒衍生的 CTL 表位发现

• 批准号: 7700154
• 金额: $ 90.35万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7700154
• 关键词: Large; Scale; Vaccinia; Virus; Derived

The Large Scale Antibody and T Cell Epitope Discovery Program supports the large scale discovery of novel B and T cell epitopes that utilize recent technological advances such as, but not limited to: computer-based epitope prediction algorithms; genome-wide scanning; structural genomic; high pressure liquid chromatography; mass spectrometry; phage-display libraries; and combinatorial synthetic peptide library screens. In addition, NIAID seeks to develop new or improved high throughput screening methods for epitope discovery, with a strong interest in antibody epitope screening methods. This program emphasizes epitope discovery for category A-C bioterrorism agents and emerging/re-emerging infectious diseases.

大规模抗体和T细胞表位发现程序支持了使用最新技术进步的新型B和T细胞表位的大规模发现，例如但不限于：基于计算机的表位预测算法；全基因组扫描；结构基因组；高压液相色谱；质谱；噬菌体播放库；和组合合成肽库筛选。此外，NIAID试图开发新的或改进的高吞吐量筛选方法来发现表位，并对抗体表位筛查方法产生了浓厚的兴趣。该计划强调了A-C类生物恐怖剂的表位发现以及新兴/重新出现的传染病。