GENETICS OF BRAIN STRUCTURE AND FUNCTION

脑结构和功能的遗传学

• 批准号: 7719261
• 负责人: PHILIP R SZESZKO
• 金额: $ 0.18万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719261
• 关键词: Anterior; Brain; Brain-Derived Neurotrophic Factor; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Grant; Hippocampus (Brain); Individual; Institution; Lead; Magnetic Resonance Imaging; Measures; Memory; Molecular; Molecular Genetics; Morphology; Patients; Play; Proteins; Research; Research Personnel; Resources; Role; Schizophrenia; Shapes; Source; Structure; Testing; United States National Institutes of Health; base; brain size; cognitive function; endophenotype; healthy volunteer; neuroimaging; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is limited data regarding the molecular basis for alterations in brain size, shape or function in schizophrenia. One gene, brain derived neurotrophic factor (BDNF), is a secreted protein that is widely expressed in the hippocampus. BDNF has been found to play a role in hippocampal morphology and associated cognitive functions such as memory. To date, few studies have examined the relationship between BDNF polymorphism and hippocampal morphology. Moreover, prior neuroimaging studies have not distinguished between the anterior and posterior hippocampus, a critical distinction given previous data suggesting that structural and functional deficits may be most robust in the anterior hippocampus in schizophrenia. In this study, we propose assessing the relationship between magnetic resonance (MR) imaging measures of brain structure/function and genetic information in 100 healthy volunteers and 100 patients with schizophrenia. We will test the hypothesis that BDNF genetic variation is associated with anterior hippocampal structure and function and abnormalities in regions to which the anterior hippocampus is connected. These data may lead to novel endophenotypes in molecular genetic studies of schizophrenia as well as a better understanding of how genes contribute to brain development in healthy individuals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 关于精神分裂症中脑大小，形状或功能改变的分子基础的数据有限。 一种基因，脑衍生的神经营养因子（BDNF）是一种分泌的蛋白质，在海马中广泛表达。 已经发现BDNF在海马形态和相关的认知功能（例如记忆）中发挥作用。 迄今为止，很少有研究检查BDNF多态性与海马形态之间的关系。 此外，先前的神经影像学研究尚未区分前海马和后海马，鉴于先前的数据表明，在精神分裂症的前海马中，结构和功能性缺陷可能最强大。 在这项研究中，我们提出了评估100名健康志愿者和100名精神分裂症患者的磁共振（MR）成像测量的磁共振（MR）成像度量之间的关系。 我们将检验以下假设：BDNF遗传变异与海马前海马的前海马结构和功能和异常相关。 这些数据可能导致精神分裂症的分子遗传研究中的新型内表型，并更好地理解基因如何对健康个体的脑发育有助于。