VAGUS NERVE STIMULATION IN RHEUMATOID ARTHRITIS (VANSRA)

迷走神经刺激治疗类风湿性关节炎 (VANSRA)

• 批准号: 7719270
• 负责人: Kevin J Tracey
• 金额: $ 11.23万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719270
• 关键词: Adverse effects; Affect; Autonomic nervous system; Cardiovascular Diseases; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; Disease Marker; Ear; Functional disorder; Funding; Goals; Grant; Heart Rate; Inflammation; Inflammatory; Institution; Joints; Measures; Morbidity - disease rate; Nervous System Physiology; Organ; Outcome; Purpose; Research; Research Personnel; Resources; Rheumatoid Arthritis; Risk; Source; United States National Institutes of Health; Vagus nerve structure; concept; human data; mortality; vagus nerve stimulation; Adverse effects; Affect; Autonomic nervous system; Cardiovascular Diseases; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; Disease Marker; Ear; Functional disorder; Funding; Goals; Grant; Heart Rate; Inflammation; Inflammatory; Institution; Joints; Measures; Morbidity - disease rate; Nervous System Physiology; Organ; Outcome; Purpose; Research; Research Personnel; Resources; Rheumatoid Arthritis; Risk; Source; United States National Institutes of Health; Vagus nerve structure; concept; human data; mortality; vagus nerve stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the short-term effects of vagus nerve stimulation (VNS) by auricular stimulation (stimulation of the auricular branch of the vagus nerve which innervates the ear) in rheumatoid arthritis (RA). RA is characterized by a chronic systemic inflammation affecting the joints but also carries an increased risk for extra-articular manifestations as well as other organ manifestations such as cardiovascular disease (CVD), which significantly contributes to morbidity and mortality in this disorder. Previously, we have studied the relationship between RA and autonomic nervous system function (ANS). Preliminary human data from this study shows that there is an association between ANS dysfunction, measured as heart rate variability and inflammatory markers in RA. Ultimately the goal of this study is to develop new treatment concepts by modulating the ANS in RA with a beneficial effect on disease markers and outcome while minimizing side-effects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是检查迷走神经刺激（VNS）的短期影响（VNS）通过耳刺刺激（刺激迷走神经的耳神经分支，这些神经的耳神经）在类风湿关节炎（RA）中的耳朵神经支配）。 RA的特征是影响关节的慢性全身性炎症，但也带来了关节外表现以及其他器官表现的风险增加，例如心血管疾病（CVD），这对这种疾病中的发病率和死亡率显着促进。 以前，我们已经研究了RA与自主神经系统功能（ANS）之间的关系。这项研究的初步人类数据表明，ANS功能障碍（以心率变异性和RA中的炎症标记）之间存在关联。最终，这项研究的目的是通过调节RA中的ANS来开发新的治疗概念，并对疾病标记和结果产生有益的影响，同时最大程度地减少副作用。