CLINICAL TRIAL: EXPLORATORY PROTEOMIC ANALYSES OF GINGIVAL CREVICULAR FLUID IN H

临床试验：H 中龈沟液的探索性蛋白质组学分析

• 批准号: 7716896
• 负责人: Steven Offenbacher
• 金额: $ 1.16万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716896
• 关键词: Advertisements; Age; Biological Markers; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Daily; Dental Hygiene; Disease; Ensure; Exhibits; Funding; Gingival Crevicular Fluid; Gingivitis; Grant; Health; Hour; Hygiene; Institution; Liquid substance; Methods; Oral cavity; Participant; Periodontitis; Phase; Placement; Procedures; Prophylactic treatment; Proteomics; Purpose; Recruitment Activity; Research; Research Personnel; Resolution; Resources; Risk; Saliva; Source; Standards of Weights and Measures; Stents; Time; Tooth structure; United States National Institutes of Health; Visit; Week; healthy volunteer; scaling and root planing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The overall purpose of this research is to identify biological markers for gum disease (gingivitis), which can be identified within the gum fluid (gingival crevicular fluid) or the saliva, that may be used to identify who is at greatest risk for developing gum disease and who responds best to treatments. Participants: Twenty-four to thirty participants, to ensure completion of twenty-four, will be recruited by advertisement. Participants will be between the ages of 18 & 65, will be in good general health and will exhibit naturally occurring (plaque-induced) gingivitis but no evidence of periodontitis. Procedures (methods): This study will involve induction of experimental gingivitis in healthy volunteers. Participants will be seen at the study center for twelve hours (8 visits) over a nine week time period. Following a one-week standard hygiene phase, participants will abstain from brushing and flossing teeth in one half of their mouths during a three week, no hygiene phase via placement of acrylic stents. Thereafter, participants will reinstate normal full mouth oral hygiene, daily plaque control and will be followed for four weeks during gingivitis resolution. Prophylaxis with scaling and root planing will be performed at exit as needed.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：这项研究的总体目的是鉴定牙龈疾病（牙龈炎）的生物学标志物，可以在牙龈液（牙龈刺激性裂缝液）或唾液中鉴定出来，这些物种可以用来识别谁对牙龈疾病的最大风险以及谁对治疗的反应最大。 参与者：将通过广告招募24至30名参与者，以确保完成二十四个参与者。 参与者的年龄将在18岁和65岁之间，将处于良好的一般健康状况，并且会表现出天然（斑块引起的）牙龈炎，但没有牙周炎的证据。 程序（方法）：这项研究将涉及健康志愿者的实验性牙龈炎。 在九周的时间段内，将在研究中心看到参与者十二个小时（8个访问）。 在一个为期一周的标准卫生阶段之后，参与者将在三个星期内弃用一半的嘴巴刷牙和牙线，而通过放置丙烯酸支架没有卫生阶段。 此后，参与者将恢复正常的全口口腔卫生，每日牙菌斑控制，并在解决牙龈炎期间进行四个星期。 根据需要，将在出口时进行缩放和根策划的预防。