ASSOCIATION OF GENOTYPE AND CIRCULATING LEVELS OF TGF?1 IN CYSTIC FIBROSIS PA

囊性纤维化 PA 中 TGF?1 基因型与循环水平的关联

• 批准号: 7716894
• 负责人: Michael R Knowles
• 金额: $ 1.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716894
• 关键词: Blood specimen; Clinic; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Immune; Institution; Lead; Measures; Purpose; Registries; Research; Research Personnel; Resources; Role; Sampling; Source; United States National Institutes of Health; Wound Healing; cystic fibrosis patients; therapeutic target; volunteer; Blood specimen; Clinic; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Immune; Institution; Lead; Measures; Purpose; Registries; Research; Research Personnel; Resources; Role; Sampling; Source; United States National Institutes of Health; Wound Healing; cystic fibrosis patients; therapeutic target; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to measure and compare levels of TGF¿1 in cystic fibrosis patients and healthy control subjects. TGF¿1 has been implicated as a potential immune modulator in CF patients with certain genotypes (results from GCRC #1774) and has been shown to alter wound repair. This study is being done to further characterize what differences (if any) exist between circulating TGF¿1 levels in CF patients with two different genotypes and in addition, to describe TGF¿1 levels in normal volunteers. The initial blood samples used to determine genotype will come from samples already collected under GCRC #1774 ?Gene Modifier Study? and the normal volunteer samples will be requested from the Environmental Polymorphisms Registry (GCRC #2140). Both groups of subjects will then be asked to come to either the GCRC or the CF clinic to have a single 35 ml blood sample drawn to measure TGF¿1 levels. A clearer understanding of the potential role of TGF¿1 may lead to further studies as a potential therapeutic target for CF.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 这项研究的目的是测量和比较囊性纤维化患者和健康对照受试者中TGF¿1的水平。在具有某些基因型的CF患者（GCRC＃1774的结果）的CF患者中，TGF¿1已被实施为潜在的免疫调节剂，并已被证明会改变伤口修复。正在进行这项研究以进一步表征具有两种不同基因型的CF患者循环TGF的差异（如果有）（如果有），并另外描述了正常志愿者中TGF的1个水平。用于确定基因型的初始血液样本将来自已经在GCRC＃1774？基因修饰剂研究中收集的样本？并且将要求从环境多态性注册表（GCRC＃2140）中要求正常的志愿者样本。然后，将要求两组受试者来到GCRC或CF诊所，以绘制35 mL血液样本，以测量TGF。对TGF¿1的潜在作用的更清晰了解可能会导致进一步的研究作为CF的潜在治疗靶点。