GENE METAL INTERACTIONS AND PARKINSON'S DISEASE

基因金属相互作用与帕金森病

• 批准号: 7719309
• 负责人: Marc Weisskopf
• 金额: $ 2.19万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719309
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Ethnic Origin; Funding; Gender; Gene Mutation; Genes; Grant; Individual; Institution; Lead; Metals; Parkinson Disease; Patients; Research; Research Personnel; Resources; Source; United States National Institutes of Health; bone; bone lead; case control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate 800 PD patients as well as 800 controls matched one to one by age, gender, ethnicity, and geographical region. The two main hypotheses are: (1) Among the cases and the controls, higher levels of lead in bone are associated with higher odds of PD case. (2) The effect of bone lead will be highest in individuals with heterozygous or homozygous for HFE gene mutation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将评估800名PD患者以及800个对照组，符合年龄，性别，种族和地理区域。 这两个主要假设是：（1）在病例和对照中，骨骼中较高的铅水平与PD病例的几率有关。 （2）在HFE基因突变的杂合或纯合子的个体中，骨骼铅的作用将最高。