In vivo high-resolution mapping of the elastic moduli and tensile stress in the human cornea

人体角膜弹性模量和拉应力的体内高分辨率绘图

• 批准号: 10633769
• 负责人: Seok-Hyun Andy Yun
• 金额: $ 55.33万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633769
• 关键词: Air; Algorithms; Beds; Biomechanics; Cadaver; Caring; Chronic; Clinic; Clinical; Clinical Data; Collagen Fiber; Cornea; Corneal Diseases; Corneal Stroma; Data; Degenerative Disorder; Development; Devices; Diagnosis; Disease; Elasticity; Equilibrium; Error Sources; Eye; Eye Banks; Family suidae; Fibrillar Collagen; Fostering; Frequencies; Glaucoma; Goals; Homeostasis; Human; Hypertension; Intervention; Keratoconus; Laser In Situ Keratomileusis; Longevity; Machine Learning; Maps; Measurement; Measures; Mechanics; Mission; Modification; Modulus; Natural regeneration; Ocular Hypertension; Operative Surgical Procedures; Optics; Outcome; Pathologic; Pathological Dilatation; Patients; Physiologic Intraocular Pressure; Play; Procedures; Process; Property; Public Health; Reading; Research; Resolution; Role; Safety; Sclera; Shapes; Stress; Structure; System; Techniques; Technology; Tissues; United States National Institutes of Health; Vision; Visual; biomechanical test; crosslink; diagnostic biomarker; elastography; first-in-human; high intraocular pressure; human data; human study; human subject; improved; in vivo; indexing; innovation; insight; instrument; interest; lens; mechanical properties; novel; public health relevance; response; screening; tonometry; tool

ABSTRACT The mechanical balance between the elastic properties and tension in the cornea plays a critical role in normal vision, refractive corrective surgery, glaucoma screening, and the management of keratoconus. Several experimental and commercial instruments are available, and they have provided clinical data that suggest the potential values of biomechanical analysis. However, these devices offer limited quantitative resolution and cannot characterize corneal elastic properties that are highly anisotropic, nonlinear, and nonuniform. The overarching goal of this project is to advance optical coherence elastography (OCE) and use this technology to measure the mechanical parameters in human corneas with unprecedented details. Built on strong preliminary data, the new OCE harnesses extensional and flexural elastic waves guided along the cornea and determines tensile modulus and shear modulus, as well as tension, from the profiles and velocities of the waves. The first specific aim will develop wideband OCE using porcine and human cadaver eyes ex vivo. Algorithms to quantify elastic moduli and tension with high precision and resolution will be verified. The second specific aim will apply wideband OCE to obtain detailed mechanical data from human corneas in vivo. The study will involve healthy subjects across the lifespan, ocular hypertension patients, keratoconus patients, and subjects undergoing refractive surgeries. The potential impact of this project is immense, as the expected data will improve our understanding of corneal biomechanics in relation to the various natural, pathological, and interventional processes, and the technological advance may lead to a new clinical tool that can improve the diagnosis and treatment of keratoconus, the accuracy of tonometry, and the safety and visual outcome of refractive surgery.

抽象的 角膜的弹性和张力之间的机械平衡起着至关重要的作用。 正常视力、屈光矫正手术、青光眼筛查和圆锥角膜的治疗。 有几种实验和商业仪器可供使用，并且它们提供的临床数据表明 提出生物力学分析的潜在价值。然而，这些设备提供的定量有限 分辨率，无法表征高度各向异性、非线性和角膜弹性特性 不均匀。该项目的总体目标是推进光学相干弹性成像（OCE）和 使用该技术以前所未有的细节测量人类角膜的机械参数。 新的 OCE 基于强大的初步数据，利用拉伸和弯曲弹性波引导 沿着角膜并根据轮廓确定拉伸模量和剪切模量以及张力 和波浪的速度。第一个具体目标是利用猪和人类开发宽带 OCE 尸体眼睛离体。高精度和分辨率量化弹性模量和张力的算法 将被验证。第二个具体目标是应用宽带 OCE 来获取详细的机械数据 人体内的角膜。该研究将涉及整个生命周期的健康受试者，高眼压症 患者、圆锥角膜患者和接受屈光手术的受试者。这的潜在影响 项目是巨大的，因为预期的数据将提高我们对角膜生物力学的理解 与各种自然、病理和介入过程以及技术进步的关系 可能会带来一种新的临床工具，可以提高圆锥角膜的诊断和治疗的准确性 眼压测量的原理，以及屈光手术的安全性和视力结果。