Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation

Chiari I 型畸形的功能连接、大脑发育和结果

• 批准号: 10629122
• 负责人: Nico Dosenbach
• 金额: $ 16.54万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629122
• 关键词: Adolescent; Adult; Age; Anatomy; Anisotropy; Attention; Brain; Brain Stem; Cerebellar tonsil; Cerebellum; Cerebrum; Child; Child Behavior Checklist; Childhood; Clinical; Clinical Treatment; Cognition; Cognitive; Data; Data Set; Development; Diffusion Magnetic Resonance Imaging; Disease; Disease Outcome; Emotional; Emotions; Executive Dysfunction; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Headache; Health; Image; Impaired cognition; Individual; Intervention; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measures; Moods; Needles; Neurobehavioral Manifestations; Operative Surgical Procedures; Outcome; Paresthesia; Participant; Pathologic; Pathology; Pathway interactions; Patients; Pediatric cohort; Pediatrics; Pontine structure; Positioning Attribute; Posterior Fossa; Protocols documentation; Radiology Specialty; Rest; Role; Sampling; Scanning; Severities; Short-Term Memory; Signs and Symptoms; Site; Spinal Canal; Spinal Cord; Standardization; Surgical Decompression; Symptoms; Testing; Time; Tonsil; United States National Institutes of Health; Work; anatomic imaging; arm; attentional control; behavior measurement; behavior test; behavioral phenotyping; cognitive development; cognitive function; cognitive testing; cohort; emotion regulation; emotional symptom; executive function; foramen magnum; imaging biomarker; improved; indexing; internal control; longitudinal analysis; malformation; motor control; neuroimaging; novel; outcome prediction; predictive marker; response; sham surgery; symptomatic improvement; treatment and outcome

PROJECT SUMMARY Project 2: Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation Abstract Chiari malformation (CM) is a challenging disease. Despite its anatomically well-defined pathology characterized by herniation of the cerebellar tonsils through the foramen magnum, its clinical symptoms and indications for surgical intervention are highly variable. Here we propose advanced neuroimaging with personalized connectomics acquired longitudinally, in both surgical (pre/post posterior fossa decompression) and non-surgical CM patients, to identify imaging markers for better disease characterization and outcome prediction. We are using resting state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI) to measure resting state functional connectivity (RSFC) and fractional anisotropy (FA), respectively. We are leveraging the protocols of the Adolescent Brain Cognitive Development (ABCD) Study (n = 11,874), to facilitate direct comparisons to age and demographic matched control subjects from the ABCD data set, for both imaging and cognitive/emotional metrics. In addition, we are collecting Chiari Severity Index (CSI) and Chiari Health Index in Pediatrics (CHIP) data, both of which have been developed and validated by our team specifically for CM. The longitudinal arm of this project includes an adult CM cohort, which will expand the number of participants for greater power, and allow us to test developmental CM effects in the pediatric cohort. The imaging and cognitive measures will be compared at baseline before any intervention. Then within-participant comparisons will be made before and after posterior fossa decompression (PFD) surgery to identify novel imaging markers predictive of disease outcomes and response to surgery.

项目概要 项目 2：Chiari I 型畸形的功能连接、大脑发育和结果 抽象的 Chiari 畸形 (CM) 是一种具有挑战性的疾病。尽管其解剖学上明确的病理学 以小脑扁桃体经枕骨大孔突出为特征，其临床症状和 手术干预的适应症差异很大。在这里，我们提出先进的神经影像学 在手术（前/后颅窝减压）中纵向获得的个性化连接组学 和非手术 CM 患者，以确定影像标记物以更好地描述疾病特征和结果 预言。我们使用静息态功能 MRI (rs-fMRI) 和扩散张量成像 (DTI) 来测量 分别是静息态功能连接（RSFC）和分数各向异性（FA）。我们正在利用 青少年大脑认知发展 (ABCD) 研究 (n = 11,874) 的协议，以促进直接 与来自 ABCD 数据集的年龄和人口统计匹配的对照受试者进行比较，包括成像和 认知/情感指标。此外，我们还收集 Chiari 严重程度指数 (CSI) 和 Chiari 健康指数 儿科 (CHIP) 数据，这两个数据都是由我们的团队专门针对 CM 开发和验证的。这 该项目的纵向部门包括一个成人 CM 队列，这将扩大参与者的数量 更大的力量，并使我们能够在儿科队列中测试发育 CM 效果。影像与认知 在进行任何干预之前，将在基线上对措施进行比较。然后参与者内部的比较将是 在后颅窝减压 (PFD) 手术之前和之后进行，以确定新的成像标记物预测 疾病结果和对手术的反应。