Pilot Project Component

试点项目组成部分

• 批准号: 7496832
• 负责人: Donita Robinson
• 金额: $ 7.88万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7496832
• 关键词: Affect; Alcoholism; Alcohols; Animals; Awareness; CYP2E1 gene; Cells; Chromosomes, Human, Pair 10; Chronic; Classification; Data; Electrophysiology (science); Eligibility Determination; Ethanol; Faculty; Feasibility Studies; Fire - disasters; Funding; Gene Expression; Genes; Genetic; Goals; Human; Investigation; Measures; Monitor; Pathology; Pattern; Pilot Projects; Process; Rattus; Research; Research Personnel; Research Project Grants; Research Support; Resources; Signal Transduction; Techniques; Translational Research; Water; alcohol exposure; alcohol research; alcohol response; alcohol sensitivity; base; design; interest; problem drinker; professor; programs; response; success

The Pilot Project program is designed to provide funds to new investigators without current or past research support and to established investigators who propose projects that represent a significant departure from their ongoing research. The goal of the program is to provide investigators with sufficient funds to obtain pilot data on alcohol research projects that can be used to support applications for research grants. A detailed review process includes internal solicitation for proposals, involvement and advice from appropriate Center faculty as well as internal and external review to select studies of the highest quality. This Alcohol Research Center includes two Pilot Projects as part of this proposal. The first is from a new UNC Assistant Professor, Dr. Donita Robinson, who will study NAc cell firing patterns during concurrent ethanol and water operant responding in rats using multineuron recording techniques. Her project will explore the effect of chronic ethanol exposure on adaptations of these electrophysiological responses. This fits nicely with the other research components exploring ethanol adaptations across the progression to alcoholism. The project will benefit from interactions with center faculty and expand our investigations to electrophysiology in behaving animals. The second Pilot Project is a translational research project led by Dr. Kirk Wilhelmsen, an Associate Professor of Genetics interested in the identification of genes associated with a low level of alcohol response. His proposal will explore how sequence changes in human CYP2E1 affect gene expression and which gene is responsible for the linkage to the signal related to low alcohol sensitivity on proximal chromosome 10. This project fits nicely with Center emphasis on cellular mechanisms of alcohol actions across the progression to alcoholism. These Pilot Projects will provide the resources for these investigators to develop preliminary findings important for success in larger research grants and to integrate with our Center research program. In years 2-5, the Center will continue to promote alcohol research across the UNC campus. By bringing in new people and new ideas, the center is constantly renewing itself. The Pilot Project program provides a means to reach out to large research faculty at UNC and increase interest and awareness regarding alcoholic pathology.

试点项目计划旨在为新调查人员提供资金，而没有当前或过去的研究 支持和既定的调查人员，他们提出了代表与之重大不同的项目 他们正在进行的研究。该计划的目的是为调查人员提供足够的资金来获得 酒精研究项目的试验数据，可用于支持研究赠款的应用。一个 详细的审查过程包括有关建议的内部征集，参与和适当的建议 中心教师以及内部和外部审查，以选择最高质量的研究。 该提案的一部分，该酒精研究中心包括两个试点项目。首先是新的 UNC助理教授Donita Robinson博士，他将在并发期间研究NAC细胞发射模式 乙醇和水作战者使用多部位记录技术在大鼠中反应。她的项目将 探索慢性乙醇暴露对这些电生理反应的适应的影响。这 与其他研究组件非常适合探索乙醇适应的过程 酗酒。该项目将受益于与中心教师的互动，并将我们的调查扩展到 行为动物的电生理学。第二个试点项目是由博士主持的转化研究项目。 柯克·威廉姆森（Kirk Wilhelmen） 低水平的酒精反应。他的建议将探讨人类CYP2E1的序列如何影响 基因表达以及哪个基因负责与低酒精敏感性有关的信号的联系 关于近端染色体10。该项目非常适合中心强调细胞机制 酒精行动在整个酒精中毒的过程中。 这些试点项目将为这些调查人员提供初步发现的资源 对于在更大的研究补助方面取得成功并与我们的中心研究计划集成至关重要。 在2 - 5年内，该中心将继续促进整个UNC校园的酒精研究。通过带来 新的人和新想法，中心不断更新自己。飞行员项目计划提供 手段与UNC接触大型研究学院，并提高人们对 酒精病理学。