E-PROOF: E-intervention for Protein Intake and Resistance Training to Optimize Function

E-PROOF：蛋白质摄入和阻力训练的电子干预以优化功能

基本信息

批准号：
10665172
负责人：
Jessica L. Krok-Schoen
金额：
$ 23.63万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10665172
关键词：
Acceleration Accounting Address Adherence Age Aging Arthritis Behavior Therapy COVID-19 pandemic Calories Cancer Intervention Cancer Patient Cancer Survivor Cancer Survivorship Clinical Comprehensive Cancer Center Consumption Control Groups Counseling Coupled Data Development Diet Dietary Intervention Dietary intake Dietitian Education Educational Intervention Educational Materials Elderly Exercise Fatigue Geriatrics Goals Health Health Care Costs Health Promotion Health behavior Heart Diseases Heart Rate Impairment Incidence Intake Intervention Knowledge Lead Lung diseases Malignant Neoplasms Mission Muscle Proteins Muscular Atrophy Nutritional Obesity Ohio Outcome Outcome Study Pain Participant Physical Function Physical assessment Population Predisposition Prevalence Process Protein Biosynthesis Proteins Public Health Randomized Randomized, Controlled Trials Recommendation Recording of previous events Research Risk Risk Reduction SARS-CoV-2 exposure Sampling Science Scientist Self Efficacy Testing Training and Education Universities Weight Weight maintenance regimen Work acceptability and feasibility adherence rate behavior change comorbidity comparison control design dietary effective intervention effectiveness evaluation efficacy evaluation exercise intervention exercise regimen experience experimental group falls follow-up functional disability good diet health related quality of life high risk human old age (65+)improved innovation insight intervention effect intervention participants mortality multiple chronic conditions muscle form muscle strength novel novel strategies online delivery peer post intervention prevent programs protein intake randomized trial recruit resistance exercise retention rate sarcopenia survivorship waist circumference

项目摘要

ABSTRACT Accounting for more than 60% of cancer survivors, older (≥65 years) cancer survivors, have a 2- to 5-fold risk of physical function impairment, compared to cancer-free controls. Physical function impairment has multiple deleterious health effects including poor health-related quality of life (HRQoL), multi-morbidity, increased falls, and all-cause mortality. One strategy to improve physical function is dietary and resistance training interventions, which improve muscle strength and mass by stimulating muscle protein synthesis. However, there are no synchronous, online diet and exercise interventions for older cancer survivors, a group at high risk for functional limitations. Thus, the E-PROOF (E-intervention for Protein Intake and Resistance Training to Optimize Function) study will examine the feasibility, acceptability, and preliminary efficacy of a 12-week randomized controlled trial of an online, tailored nutritional and resistance training education and counseling intervention to improve physical function and associated health outcomes (muscle strength, HRQoL, self-efficacy, and weight management). We postulate that, compared to the control group, intervention participants would experience statistically significant, clinically meaningful improvements in physical function and associated health outcomes following the 12-week diet and resistance training intervention. To achieve our objective, we will: 1) Determine the feasibility and acceptability of implementing an online dietary and resistance training intervention among 70 older cancer survivors; and; 2) Examine the preliminary efficacy of an online dietary and resistance training intervention to improve physical function and associated outcomes among 70 older cancer survivors who participated in a 12- week intervention. In this pilot randomized controlled trial, participants will be randomized to one of two groups: one experimental (online counseling by a registered dietitian and exercise scientist, menus, educational materials on protein, healthy diet, resistance training) and one control (general survivorship education). We will examine the intervention effects on physical function, muscle strength, HRQoL, self-efficacy, weight, and waist circumference during a 12-week period between the experimental and control groups. We will conduct a 3-month follow-up to assess physical function, muscle strength, and HRQoL. The feasibility of conducting an online diet and resistance training intervention in older cancer survivors will be determined by the study accrual, retention, and adherence rates. This study will inform the development of a R01 scale randomized controlled trial to evaluate the effectiveness of a protein-focused meal delivery program and resistance exercise regimen on risk for functional impairment and sarcopenia among older cancer survivors. The study goals respond to the NIA and NCI missions to address the research gaps in older cancer survivors and help them lead longer, healthier lives. This novel study advances science by promoting independent health behaviors among older cancer survivors, which can improve health outcomes and provide foundational knowledge to further address this growing problem on a wider scale through online platforms.

抽象的占癌症幸存者的 60% 以上，年龄较大（≥65 岁）的癌症幸存者罹患癌症的风险是其 2 至 5 倍与无癌症对照相比，身体功能受损有多种。有害的健康影响，包括与健康相关的生活质量 (HRQoL) 较差、多种发病率、跌倒次数增加、改善身体机能的一项策略是饮食和阻力训练干预，通过刺激肌肉蛋白质合成来提高肌肉力量和质量，但目前还没有。对老年癌症幸存者（功能障碍高风险群体）进行同步在线饮食和运动干预因此，E-PROOF（蛋白质摄入和阻力训练的电子干预以优化功能）。研究将检验为期 12 周的随机对照试验的可行性、可接受性和初步疗效在线、定制的营养和阻力训练教育和咨询干预，以改善身体状况功能和相关的健康结果（肌肉力量、HRQoL、自我效能和体重管理）。假设与对照组相比，干预参与者将经历统计显着性， 12 周后身体机能和相关健康结果出现具有临床意义的改善为了实现我们的目标，我们将： 1) 确定可行性和在 70 名老年癌症患者中实施在线饮食和阻力训练干预的可接受性幸存者；以及；2) 检查在线饮食和阻力训练干预的初步效果改善参与 12 项研究的 70 名老年癌症幸存者的身体机能和相关结果周干预在这项随机对照试验中，参与者将被随机分为两组：一项实验（由注册营养师和运动科学家提供的在线咨询、菜单、教育我们将提供有关蛋白质、健康饮食、抵抗训练的材料）和一项对照（一般生存教育）。检查干预对身体功能、肌肉力量、HRQoL、自我效能、体重和腰围的影响我们将在实验组和对照组之间进行为期 3 个月的为期 12 周的周长测量。后续评估身体机能、肌肉力量和 HRQoL 进行在线饮食的可行性。老年癌症幸存者的阻力训练干预将取决于研究的累积、保留、本研究将为 R01 量表随机对照试验的开发提供信息。评估以蛋白质为重点的膳食计划和阻力运动方案对风险的有效性该研究的目标是针对老年癌症幸存者的功能障碍和肌肉减少症。 NCI 的使命是解决老年癌症幸存者的研究空白，帮助他们过上更长寿、更健康的生活。这项新颖的研究通过促进老年癌症幸存者的独立健康行为来推动科学发展，可以改善健康状况并提供基础知识以进一步解决这一日益严重的问题通过线上平台进行更广泛的推广。