Project 3: Nicotine Product Claims on Appeal, Perceptions, and Use Behavior

项目 3：尼古丁产品声称的吸引力、认知和使用行为

• 批准号: 10666069
• 负责人: Darren M Mays
• 金额: $ 46.42万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666069
• 关键词: Address; Adult; Affect; Behavior; Behavioral; Cigarette; Cognitive; Color; Communication; Dependence; Dimensions; Electronic cigarette; Future; Goals; Harm Reduction; Human; Industry; Label; Laboratories; Marketing; Measures; Methods; Modified Risk Tobacco Product; Nicotine; Nicotine Dependence; Ohio; Oral; Perception; Persons; Predisposition; Proliferating; Psychophysiology; Public Health; Regulation; Risk; Sales; Sampling; Science; Smokeless Tobacco; Smoker; Source; Tobacco; Tobacco Industry; Toxic effect; Universities; Visual; abuse liability; behavior measurement; behavioral economics; design; experimental study; innovation; interest; laboratory experiment; novel; novel strategies; preference; risk perception; smokeless tobacco user; tobacco products; tobacco regulatory science; tobacco user; tobacco-free; tool; young adult

SUMMARY – PROJECT 3 Oral nicotine pouches (ONPs) emerged in the U.S. in 2016, ONP brands rapidly proliferated, and sales are skyrocketing. ONPs are representative of a shift by the tobacco industry to marketing non-tobacco nicotine products as alternatives to cigarettes, smokeless tobacco (ST), and even e-cigarettes (ECs). Nicotine is the driver of use and dependence, and the industry continuously manipulates nicotine dimensions to maximize appeal to consumers. Packaging is a primary marketing vehicle to increase product appeal, and ONP packaging prominently emphasizes nicotine concentration (e.g., 3 mg, 6 mg) and source claims (e.g., “tobacco free”) as a marketing tool. Understanding how these packaging features communicating nicotine dimensions affect the appeal of ONPs in young adult non-users versus adult tobacco users is critical to inform regulations for ONPs and other nicotine products using similar marketing. Project 3 of the Ohio State University Tobacco Center of Regulatory Science (OSU-TCORS) will examine how nicotine concentration and source claims on ONP packaging affect the appeal of ONPs and how these features affect preferences for ONPs relative to ECs, cigarettes, ST, and other products in young non-tobacco users versus adult tobacco users. The Specific Aims are to: 1) Examine the effects of nicotine concentration and source claims on visual and cognitive engagement with ONP packaging using laboratory-based psychophysiological assessment. 2) Examine the effects of nicotine concentration and source claims on ONP perceptions, behavioral intentions, and ONP trial. 3) Investigate the effects of nicotine concentration and source claims on ONP preferences relative to ECs, cigarettes, ST, and other tobacco products. Project 3 includes 2 complementary studies to accomplish these aims. Study 1 (Aims 1 and 2) is a 2 (young adult susceptible non-user, adult tobacco user) x 3 (labelled nicotine concentration: none, low, high) x 3 (source claim: none, “tobacco free,” “synthetic”) human laboratory experiment to examine how nicotine concentration and source claims affect engagement with ONP packaging using psychophysiological measures, ONP appeal, risk perceptions and use intentions, and a behavioral lapse task assessing ONP trial. Study 2 (Aim 3) is a discrete choice experiment with a national sample of young adult susceptible non-users and adult tobacco users to assess the effects of nicotine concentration and source claims on ONP preferences relative to ECs, cigarettes, ST, and other products. Project 3 addresses the Marketing Influences and Behavior FDA tobacco regulatory science domains. Project 3 is significant and innovative because it will be one of the first studies to generate evidence to inform potential regulation of packaging features communicating nicotine concentration and nicotine source claims based on their differential effects in young adult non-users versus adult tobacco users. Through integration with Projects 1, 2, and 4, the OSU-TCORS will provide evidence to guide an overall regulatory strategy targeting nicotine dimensions for ONPs, ECs, and other novel products.

摘要 – 项目 3 2016年，口服尼古丁袋（ONP）在美国出现，ONP品牌迅速激增，销量 ONP 的飙升代表了烟草业向营销非烟草尼古丁的转变。 产品作为香烟、无烟烟草（ST）甚至电子烟（EC）的替代品。 使用和依赖的驱动因素，并且该行业不断操纵尼古丁尺寸以最大化 包装是增加产品吸引力的主要营销工具，而 ONP 包装 突出强调尼古丁浓度（例如 3 毫克、6 毫克）和来源声明（例如“不含烟草”） 了解这些传达尼古丁含量的包装特征如何影响 与成年烟草使用者相比，ONP 对年轻成人非使用者的吸引力对于为 ONP 法规提供信息至关重要 和其他尼古丁产品使用类似的营销项目 3 的俄亥俄州立大学烟草中心。 监管科学 (OSU-TCORS) 将研究 ONP 上的尼古丁浓度和来源声明 包装会影响 ONP 的吸引力，以及这些特征如何影响 ONP 相对于 EC 的偏好， 年轻非烟草使用者与成年烟草使用者的卷烟、无烟烟草和其他产品的具体目标。 目的是： 1) 检查尼古丁浓度和来源声明对视觉和认知参与的影响 使用基于实验室的心理生理学评估的 ONP 包装 2) 检查尼古丁的影响。 ONP 认知、行为意图和 ONP 试验的浓度和来源主张 3) 调查 ONP 试验。 尼古丁浓度和来源声明对 ONP 偏好（相对于 EC、卷烟、ST 和 项目 3 包括 2 项补充研究以实现这些目标（目标）。 1 和 2) 是 2（易受影响的非使用者的年轻成人，成年烟草使用者）x 3（标记的尼古丁浓度：无， 低、高）x 3（来源声明：无、“无烟草”、“合成”）人体实验室实验，以检查如何 尼古丁浓度和来源声明会影响使用心理生理学的 ONP 包装的参与度 措施、ONP 上诉、风险认知和使用意图，以及评估 ONP 试验的行为失误任务。 研究 2（目标 3）是一项离散选择实验，以易受影响的非使用者的全国样本为对象， 成年烟草使用者评估尼古丁浓度和来源声明对 ONP 偏好的影响 相对于 EC、香烟、ST 和其他产品，项目 3 解决了营销影响和行为。 FDA 烟草监管科学领域项目 3 具有重要意义和创新性，因为它将成为其中之一。 第一项研究旨在生成证据，为传达尼古丁的包装特征的潜在监管提供信息 浓度和尼古丁来源声明基于其对年轻成人非使用者与成人的不同影响 通过与项目 1、2 和 4 整合，OSU-TCORS 将提供证据来指导。 针对 ONP、EC 和其他新产品的尼古丁含量的总体监管策略。