STUDIES OF NATURAL SIV-INFECTION IN SOOTY MANGABEYS

乌白眉猴自然感染 SIV 的研究

• 批准号: 7715856
• 负责人: Guido Silvestri
• 金额: $ 8.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715856
• 关键词: Acquired Immunodeficiency Syndrome; African; Cercocebus atys; Computer Retrieval of Information on Scientific Projects Database; Data; Employee Strikes; Funding; Grant; HIV; HIV Infections; Human; Individual; Infection; Institution; Monkeys; Phenotype; Research; Research Personnel; Resources; SIV; Source; United States National Institutes of Health; Virus; Virus Diseases

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on understanding the reasons why natural hosts for Simian Immunodeficiency Virus infection, such the African monkey species sooty mangabeys, in striking contrast to what happens in HIV-infected individuals, are not susceptible to AIDS despite being infected with a virus that replicates continuously and at very high levels. A better definition of the mechanisms underlying this phenotype may provide clues to understanding the reasons why humans infected with HIV develop AIDS. This data will pave the way to new therapies for HIV infection.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的重点是理解自然宿主为猿猴免疫缺陷病毒感染的原因，例如非洲猴子烟草芒果，与艾滋病毒感染者中发生的事情形成了鲜明的对比，尽管受到艾滋病的影响，但仍被艾滋病感染而受到艾滋病的影响，从而连续地复制了艾滋病。 对本表型基础机制的更好定义可以为理解感染HIV发展艾滋病的原因提供线索。这些数据将为艾滋病毒感染的新疗法铺平道路。