CENTRAL VASOPRESSIN RECEPTORS AND AFFILIATION

中枢加压素受体及其隶属关系

• 批准号: 7715697
• 负责人: Larry J Young
• 金额: $ 2.14万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715697
• 关键词: Autistic Disorder; Behavior; Computer Retrieval of Information on Scientific Projects Database; Corticotropin-Releasing Hormone; Evolution; Female; Funding; Grant; Hypothalamic structure; Institution; Investigation; Mental disorders; Microsatellite Repeats; Neuropeptides; Nucleus Accumbens; Oxytocin; Oxytocin Receptor; Primates; Regulation; Research; Research Personnel; Resources; Role; Social Behavior; Source; Surveys; System; United States National Institutes of Health; Vasopressin Receptor; Vasopressins; Viral Vector; depressive symptoms; male; paraventricular nucleus; prairie vole; preference; promoter; receptor density

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using viral vector over-expression, we demonstrated that increasing oxytocin receptor density in the prairie vole nucleus accumbens facilitates partner preference formation in females. We found that the source of oxytocin in the accumbens is the paraventricular nucleus of the hypothalamus. We demonstrated the CRF facilitates partner preference formation in the male prairie vole. Additionally, studies concluded that loss of a partner leads to the emergence of depressive like behavior in male prairie voles and that this change in emotionality is regulated by the CRF system. A survey of the vasopressin receptor promoter in several primate species was conducted which determined that a behaviorally relevant microsatellite in the promoter has diverged during primate evolution. This result has important implications for the evolution of social behavior and for understanding psychiatric disorders such as autism. Further investigation of the role of neuropeptides, cluding oxytocin, vasopressin and corticotropin releasing factor (CRF) in the regulation of social behavior is planned.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用病毒载体的过表达，我们证明了八氧化核酸核的氧化核受体密度增加，伏伏核核心促进了女性的伴侣偏好形成。 我们发现伏伏剂中的催产素的来源是下丘脑的旁脑核。 我们证明了CRF促进了男性草原Vole中的伴侣偏好形成。 此外，研究得出的结论是，伴侣的丧失导致雄性草原田鼠的抑郁症类似行为的出现，而情绪的这种变化受到CRF系统的调节。 对几种灵长类动物物种中的加压素受体启动子进行了调查，该调查确定启动子中具有行为相关的微卫星在灵长类动物进化过程中已经有所不同。 该结果对社会行为的发展和理解自闭症等精神疾病具有重要意义。 计划进一步研究神经肽的作用，cludo肽，加压素，加压素和皮质激素释放因子（CRF）在社会行为调节中的作用。