Sun Exposure and Melanoma in Agricultural Workers

农业工人的阳光照射与黑色素瘤

• 批准号: 7627942
• 负责人: LESLIE K DENNIS
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627942
• 关键词: Affect; Agricultural Workers; Agriculture; Attitude; Behavior; Behavior Therapy; Behavioral; Behavioral Research; Biometry; Burn injury; Cancer Control; Cancer Etiology; Characteristics; Chronic; Cohort Studies; Complex; Computers; Cream; Cutaneous Melanoma; Data; Development; Development Plans; Environmental Exposure; Environmental Risk Factor; Epidemiology; Etiology; Exposure to; Eye Burns; Eye Color; Farming environment; Focus Groups; Fostering; Funding; Hair Color; Health; Health education; Hour; Incidence; Interview; Iowa; K-Series Research Career Programs; Lead; Learning; Measurement; Measures; Mentors; National Cancer Institute; Nested Case-Control Study; North Carolina; Pesticides; Photosensitivity; Plants; Population; Prevention; Prevention Research; Property; Psychometrics; Qualitative Methods; Qualitative Research; Questionnaires; Recording of previous events; Research; Research Methodology; Research Personnel; Research Project Grants; Rest; Risk; Skin; Skin Cancer; Skin tanning; Spouses; Sun Exposure; Sunburn; Surveys; Techniques; Telephone Interviews; The Sun; Time; Training; Ultraviolet Rays; Universities; Work; base; behavioral health; cancer prevention; career development; cohort; design; farmer; melanoma; programs; prospective; protective behavior; skills; sun protection

DESCRIPTION (provided by applicant): This K07 Career Development Award application is designed to expand my career development from cancer etiology to cancer prevention and control. The career development plan rests on mentoring directed by experts in cancer prevention research and "protected time" to foster my professional development as an independent cancer control researcher. While I have training and expertise in epidemiology and biostatistics, it is becoming clear that my career development requires more specific exposure to behavioral research methodologies and behavioral intervention techniques. A unique population, the Agricultural Health Study (AHS) cohort, will be used to examine sun exposure, sun protection behavior, and factors affecting these behaviors regarding the risk of melanoma in private pesticide applicators (farmers) and their spouses. This career development program integrates my statistical and epidemiologic expertise for analyzing existing data in Year 1, with Behavioral Health education to develop my skills in measurement of factors affecting behavior and skills to design and conduct behavioral interventions. In Year 1, I will take courses and spend 2 weeks at the National Cancer Institute learning more about the Agricultural Health Study (AHS) and its measurement of environmental exposures under my co-mentor Dr. Michael Alavanja to guide my analysis of existing baseline data on the cohort related to melanoma. I will then work with my mentor Dr. John Lowe at the University of Iowa during Years 2-5 to expand my survey skills to conducting focus groups, examining behavioral factors, and behavioral attitudes, and develop skills in behavioral interventions. The research plan proposes to examine skin melanoma within this prospective cohort of private applicators (mostly farmers) and their spouses in Iowa and North Carolina (the AHS) in association with environmental factors. The specific aims are as follows: Aim 1 is to examine the risk of melanoma in the AHS cohort using various existing measures of sun exposure adjusted for skin sensitivity and sun protection. Aim 2 is to conduct qualitative research using focus groups to design appropriate measures of sun exposure, sun protection behavior, and factors affecting these behaviors in private applicators and their spouses within the AHS. Aim 3 is to conduct a nested case-control study of melanoma within the AHS cohort to examine in more detail sun exposure histories and protective behavior. Aim 4 is to use the results from the cohort and nested case-control studies to design a behavioral intervention. These aims will lead to the development of a R01 proposal to a) survey the whole AHS cohort about sun exposure, and to b) conduct a behavioral intervention as an independent cancer control researcher.

描述（由申请人提供）：该K07职业发展奖申请旨在将我的职业发展从癌症病因学到预防和控制。 职业发展计划取决于由癌症预防研究专家指导的指导，并“保护时间”以促进我作为独立癌症控制研究员的专业发展。 尽管我拥有流行病学和生物统计学方面的培训和专业知识，但越来越明显的是，我的职业发展需要更具体地接触行为研究方法论和行为干预技术。 独特的人群，农业健康研究（AHS）队列，将用于检查日晒，防晒行为以及影响这些行为的因素，这些行为影响了私人农药施用者（农民）及其配偶的黑色素瘤风险。 该职业发展计划将我的统计和流行病学专业知识整合在一起，以分析第1年的现有数据，并与行为健康教育一起发展我的技能，以衡量影响行为和技能的因素，以设计和进行行为干预。 在第一年，我将参加课程，并在美国国家癌症研究所（National Cancer Institute）花2周的时间，了解有关农业健康研究（AHS）及其在我的同事Michael Alavanja博士下对环境暴露的测量，以指导我对与黑色素瘤相关的同伙现有的碱性数据的分析。 然后，我将在2 - 5年期间与爱荷华大学的导师约翰·洛（John Lowe）合作，以将我的调查技能扩展到进行焦点小组，检查行为因素和行为态度，并发展行为干预方面的技能。 该研究计划建议在这一潜在的私人申请者（主要是农民）及其配偶在爱荷华州和北卡罗来纳州（AHS）中检查皮肤黑色素瘤与环境因素。 具体目的如下：AIM 1是使用针对皮肤敏感性和防晒的各种现有的太阳暴露量来检查AHS队列中黑色素瘤的风险。 AIM 2是使用焦点小组进行定性研究，以设计适当的阳光暴露，防晒行为以及影响私人施加者及其配偶中这些行为的因素。 AIM 3是对AHS队列中黑色素瘤进行嵌套的病例对照研究，以更详细地检查日晒历史和保护行为。 AIM 4是使用队列和嵌套的病例对照研究的结果来设计行为干预。 这些目标将导致R01提案的发展，以a）调查整个AHS队列有关日晒的信息，b）作为独立的癌症控制研究员进行行为干预。