Measuring Preferences for Fertility in Breast Cancer for a Decision Aid

测量乳腺癌患者的生育偏好以帮助决策

• 批准号: 7645193
• 负责人: CHRISTINE MARY DUFFY
• 金额: $ 13.23万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7645193
• 关键词: 21 year old; Abate; Advocate; Affect; Benefits and Risks; Biological Preservation; Cancer Patient; Cancer Survivor; Decision Aid; Decision Making; Decision Modeling; Diagnosis; Face; Fertility; Fertility Preferences; Focus Groups; Future; Glean; Health; Knowledge; Life; Measures; Methods; Modeling; Morbidity - disease rate; Operative Surgical Procedures; Outcome; Patient Preferences; Patients; Population; Process; Quality of life; Radiation therapy; Recurrence; Research; Risk; Sampling; Testing; Time; Utility Theories; Woman; base; cancer therapy; chemotherapy; malignant breast neoplasm; mortality; preference; time use; tool

DESCRIPTION (provided by applicant): Women diagnosed with breast cancer must not only face a variety of invasive, lengthy treatments that can involve surgery, chemotherapy, and radiation therapy, they also often face a threat to their fertility as a result of these treatments. Young women who have undergone cancer treatment consistently identify fertility concerns among the most troubling issues and these concerns do not abate with time. Options for preserving fertility are available, but decisions to pursue available options complicated as these decisions potentially affect a woman's risk for recurrence, mortality, and her quality of life. When there is no single option to be advocated, it is imperative to incorporate a woman's preferences into the decision making process. Decision aids can assist with difficult decisions that involve evaluating uncertain scientific evidence and weighing the benefits and risks of treatment options. They have been found to be acceptable to patients and feasible to implement. The Specific Aims of this project are to: 1) Characterize the decision making needs of young (aged 21-45) breast cancer patients regarding fertility preservation by conducting focus groups that explore the knowledge, personal risk information, and weighing of competing factors; 2) Develop a decision analytic model of the fertility preservation decision in women with breast cancer, based on information gleaned from qualitative studies; 3) Measure the preferences for fertility preservation in young women diagnosed with breast cancer, using the Time Trade-Off method derived from expected utility theory; 4) Develop a decision aid for the fertility preservation decision using the decision model; 5) Pilot test the decision aid in a small sample of young women diagnosed with breast cancer who are at risk of fertility loss and are facing the fertility preservation decision. This research will be the first decision aid for fertility preservation decisions in a breast cancer population that specifically incorporates patient preferences. The information gained from this research will be invaluable in developing future tools for women to make decisions regarding fertility and will have a beneficial effect on breast cancer survivors' lives, and relieve morbidity associated with cancer treatments.

描述（由申请人提供）：被诊断出患有乳腺癌的妇女不仅必须面临各种涉及手术，化学疗法和放射疗法的侵入性，冗长的治疗，而且由于这些治疗，她们也经常面临对生育能力的威胁。接受过癌症治疗的年轻妇女始终确定最令人不安的问题之间的生育问题，这些问题不会随着时间而减轻。可以提供保留生育能力的选择，但是要采取可用选择的决定复杂，因为这些决定可能会影响妇女复发，死亡率和生活质量的风险。如果没有单一的选择要提倡，则必须将女性的偏好纳入决策过程。决策辅助工具可以帮助做出艰难的决策，涉及评估不确定的科学证据并权衡治疗选择的益处和风险。发现它们是可以接受的，可以实施可行。该项目的具体目的是：1）表征年轻人（21-45岁）乳腺癌患者对生育能力保存的决策需求，通过探索知识，个人风险信息和权衡竞争因素的焦点小组来保存生育能力； 2）根据定性研究收集的信息，开发了乳腺癌女性生育能力保存决定的决策分析模型； 3）使用源自预期效用理论的时间权衡方法，测量被诊断为乳腺癌的年轻女性的偏好； 4）使用决策模型为生育保存决策制定决策援助； 5）试点测试一小部分被诊断出患有生育能力损失并面临生育能力决定的年轻妇女样本中的决策援助。这项研究将是专门纳入患者偏爱的乳腺癌人群中生育决策的首次决策。从这项研究中获得的信息对于为妇女制定生育决策的未来工具将是无价的，并将对乳腺癌幸存者的生活产生有益的影响，并减轻与癌症治疗相关的发病率。