OXYTOCIN AND SOCIAL ATTACHMENT

催产素和社交依恋

• 批准号: 7715680
• 负责人: Larry J Young
• 金额: $ 2.14万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715680
• 关键词: Animal Model; Autistic Disorder; Brain; Cerebrospinal Fluid; Childhood; Computer Retrieval of Information on Scientific Projects Database; Development; Female; Funding; Grant; Institution; Label; Neurons; Neuropeptides; Nucleus Accumbens; Oxytocin; Oxytocin Receptor; Pair Bond; Pharmacotherapy; Regulation; Research; Research Personnel; Resources; Role; Social Behavior; Source; Techniques; United States National Institutes of Health; Woman; Work; adeno-associated viral vector; autism spectrum disorder; neglect; paraventricular nucleus; prairie vole; receptor expression; social; social attachment; social cognition; Animal Model; Autistic Disorder; Brain; Cerebrospinal Fluid; Childhood; Computer Retrieval of Information on Scientific Projects Database; Development; Female; Funding; Grant; Institution; Label; Neurons; Neuropeptides; Nucleus Accumbens; Oxytocin; Oxytocin Receptor; Pair Bond; Pharmacotherapy; Regulation; Research; Research Personnel; Resources; Role; Social Behavior; Source; Techniques; United States National Institutes of Health; Woman; Work; adeno-associated viral vector; autism spectrum disorder; neglect; paraventricular nucleus; prairie vole; receptor expression; social; social attachment; social cognition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our work demonstrates that oxytocin is released in the nucleus accumbens during pair bond formation in female prairie voles. Using retrograde labeling techniques we determined that the oxytocin released within the accumbens originates from oxytocinergic neurons within the paraventricular nucleus. We also developed an adeno-associated viral vector to over-express the oxytocin receptor in the prairie vole brain. Our work shows that increasing oxytocin receptor expression in the accumbens facilitates social attachments and that women who have suffered abuse or neglect in childhood have decreased oxytocin concentrations in the cerebrospinal fluid. Oxytocin has recently been shown to enhance social cognition in autism spectrum disorders. Our studies in prairie voles have important implications for the development of potential drug therapies for autism. This study seeks to understand the role of the neuropeptide oxytocin in the regulation of social behavior. The highly social and monogamous prairie vole is an excellent animal model for investigating the role of oxytocin.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的工作表明，在雌性草原田鼠的成对键形成期间，在伏隔核中释放了催产素。 使用逆行标记技术，我们确定在伏隔中释放的催产素起源于脊髓脑核内的催产素能神经元。 我们还开发了一种与腺相关的病毒载体，以过表达草原vole脑中的催产素受体。 我们的工作表明，伏伏糖蛋白受体的表达增加促进了社会依恋，并且在童年时期遭受虐待或忽视的妇女在脑脊液中降低了催产素的浓度。 最近已显示催产素可以增强自闭症谱系障碍的社会认知。 我们对草原田鼠的研究对自闭症的潜在药物疗法的发展具有重要意义。这项研究试图了解神经肽氧毒素在社会行为调节中的作用。 高度社交和一夫一妻制的草原vole是研究催产素作用的出色动物模型。