Small Animal Imaging Core

小动物成像核心

• 批准号: 7683986
• 负责人: Weili Lin
• 金额: $ 11.51万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7683986
• 关键词: Animals; Biodistribution; Characteristics; Contrast Media; Development; Dose; Effectiveness; Equipment; Event; Funding; Goals; Grant; Half-Life; Housing; Image; Image Analysis; Imaging Techniques; Imaging technology; Internet; Lesion; Longitudinal Studies; Magnetic Resonance Imaging; Methods; Modality; Molecular; Monitor; National Center for Research Resources; Optical Tomography; Research; Research Infrastructure; Research Personnel; Resolution; Signal Transduction; Site; System; Time; X-Ray Computed Tomography; base; design; improved; in vivo; instrumentation; iron oxide; nanoparticle; novel; optical imaging; research study; response; single photon emission computed tomography; tool; treatment effect

Small Animal Imaging Core The main goal of this small animal imaging (SAI) core is to support the proposed projects 1 - 4. Specifically, we will establish/develop the required imaging systems and methods so as to critically evaluate the nanoparticles developed in projects 1, 2 and 4 regarding their bio-distribution, half-life, effectiveness of providing imaging contrast, and potential ability to depict molecular events. In addition, imaging methods and image analysis tools focusing on monitoring lesion progression will also be developed. Furthermore, a direct comparison of the image quality between the proposed SAI computed tomography (CT) system in project 3 and a commercially available SAI CT will be conducted in order to provide strategies for the design of the proposed CT system. Currently, the small animal imaging facility at UNC houses a 3T magnetic resonance imaging (MRI) scanner, single photon emission computed tomography (SPECT) system, and in vivo optical imaging system. While these imaging systems are capable of providing high quality small animal images, additional developments specifically to serve the needs of the proposed projects 1 - 4 are needed. To this end, we will purchase and establish a high field SAI MR scanner to provide much higher spatial resolution images and improved sensitivity to iron oxide based contrast agents (proposed in projects 1, 2, and 4) in Aim 1a. A commercially available CT system will be purchased in Aim 1b to provide high quality and stable CT images for longitudinal studies. Aim 1c will further establish a web site that manages machine times and accesses to a dedicated PACS system. In contrast, Aim 2 will focus on developing/evaluating the nanoparticles developed in projects 1, 2, and 4 by utilizing MR, SPECT, and Ol (Aim 2a), direct comparing results from project 3 and that obtained from a commercially available CT system (Aim 2b), and developing multi-modality image analysis tools (Aim 2c).

小动物成像核心 这个小动物成像（SAI）核心的主要目标是支持拟议的项目1-4。 具体而言，我们将建立/开发所需的成像系统和方法，以便对 评估项目1、2和4中开发的纳米颗粒有关其生物分布的半衰期， 提供成像对比度以及描述分子事件的潜在能力的有效性。此外， 集中于监测病变进展的成像方法和图像分析工具也将是 发达。此外，对所提出的SAI计算的图像质量的直接比较 项目3中的层析成像（CT）系统，将进行市售的SAI CT，以便为了 为拟议的CT系统的设计提供策略。目前，小型动物成像设施 在UNC内容纳3T磁共振成像（MRI）扫描仪，计算出单光子发射 断层扫描（SPECT）系统和体内光学成像系统。这些成像系统是 能够提供高质量的小动物图像，专门为服务 拟议项目1-4的需求是需要的。为此，我们将购买并建立一个高领域 SAI MR扫描仪提供更高的空间分辨率图像和对铁氧化铁的敏感性提高 AIM 1A中的基于造影剂（在项目1、2和4中提出）。市售的CT系统 将在AIM 1B中购买，以提供纵向研究的高质量和稳定的CT图像。 AIM 1C 将进一步建立一个管理机器时间并访问专用PAC系统的网站。 相比之下，AIM 2将专注于开发/评估项目1、2和4中开发的纳米颗粒 通过利用MR，SPECT和OL（AIM 2A），直接比较项目3的结果 市售的CT系统（AIM 2B），并开发多模式图像分析工具（AIM 2C）。