Center of Nanotechnology for Treatment, Understanding, *

纳米技术治疗、理解中心，*

• 批准号: 7647527
• 负责人: SADIK ESENER
• 金额: $ 2.34万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7647527
• 关键词: Achievement; Address; Adopted; Adverse effects; Antigens; Area; Biotechnology; California; Cancer Center; Cancer Patient; Cancerous; Clinic; Complex; Computing Methodologies; Decision Making; Detection; Development; Devices; Diagnosis; Diagnostic; Drug Delivery Systems; Early Diagnosis; Engineering; Facility Construction Funding Category; Goals; Image; Immune system; In Situ; Institutes; Invasive; Lead; Malignant Neoplasms; Marketing; Methods; Modeling; Monitor; Mothers; NCI Center for Cancer Research; Nanotechnology; Oncologist; Outcome; Participant; Play; Production; Research; Research Personnel; Residual Cancers; Reticuloendothelial System; Role; Shipping; Ships; Site; System; Technology; Temperature; Testing; Therapeutic; Therapeutic Agents; Universities; base; cancer cell; improved; nanoparticle; nanoscale; nanosensors; novel; programs; response; targeted delivery; therapeutic target; tumor; tumor progression

The Center of Excellence of NANOtechnology for Treatment, Understanding, and Monitoring of Cancer (NANO-TUMOR) has been established to perfect a practical nanotechnology base to diagnose, treat, and monitor cancers. Our goal is the development, of a multi-functional "smart mothership" platform that will: (1) evade the reticuloendothelial system and immune system, while attaching specifically to the tumor and its vasculature; (2) assemble a multi-functional complex at the tumor site; (3) deliver payloads of both nanosensors and therapeutics that are activated in situ. The NANO-TUMOR Center has brought together a team of investigators from the University of California, San Diego, Santa Barbara, Irvine, and Riverside campuses, the Burnham Institute and NanoBioNexus. The NANO-TUMOR Center research program is comprised of six interacting projects, each utilizing newly developed and unique technologies that when integrated together willlead to the realization of our goal. The six projects focus on (1) the production of tumor-targeted, non-toxic nanoparticles, (2) the development of a nanoporous micro-platform carrying nanosensors, imaging and therapeutic agents, (3) the creation of tumor-directed amplification systems for sensing and drug delivery, (4) the construction of devices for tumor molecule purification and characterization at a nanoscale level, (5) the application of new computational methods for longitudinal monitoring and analyses of tumor progression and response to therapy, and (6) the in situ assembly and delivery of targeted therapeutics with a smart nanotechnology platform. The Center has been organized using a novel, engineering-type decision and workflow model: Multiple approaches have been proposed to address each project, with go/no go decisions made based on achievement of milestones. The NANOTUMOR project leaders have previously founded more than 20 successful biotechnology companies, with a total market value of over two billion dollars, evidence of their ability to move discoveries to useful applications in the marketplace. The intent of the NANO-TUMOR Center to develop clinically useful platforms is also demonstrated by the strategic role that clinicians from the UCSD Cancer Center, and participants from major corporations (General Electric, Honeywell, Nanogen, Enterprise) will play in evaluating the research.

纳米技术的卓越中心用于治疗，理解和监测癌症 （纳米肿瘤）已建立以完善实用的纳米技术基础，以诊断，治疗和 监测癌症。我们的目标是一个多功能“智能母舰”平台的发展：（1） 逃避网状内皮系统和免疫系统，同时专门连接到肿瘤及其 脉管系统； （2）在肿瘤部位组装多功能复合物； （3）两者的有效载荷 原位激活的纳米传感器和治疗剂。纳米肿瘤中心已将 加州大学圣地亚哥大学，圣塔芭芭拉，尔湾和河滨的调查人员团队 校园，伯纳姆研究所和纳米牛肉。纳米肿瘤中心研究计划是 由六个互动项目组成，每个项目都利用新开发和独特的技术 将我们的目标实现结合在一起。六个项目的重点是（1）生产 靶向肿瘤的无毒纳米颗粒，（2）纳米多孔微平原携带的发展 纳米传感器，成像和治疗剂，（3）创建肿瘤定向的扩增系统 感应和药物递送，（4）建造用于肿瘤分子纯化的设备和 在纳米级的表征，（5）新计算方法在纵向上的应用 监测和分析肿瘤进展和对治疗的反应，以及（6）原位组装和 通过智能纳米技术平台传递目标治疗剂。中心已经组织 使用小说，工程类型的决策和工作流模型：已提出了多种方法 解决每个项目，并根据基于里程碑的成就做出决定。纳米量 项目领导者以前已经成立了20多家成功的生物技术公司 总市场价值超过20亿美元，证明了他们将发现转移到有用的能力 市场上的应用。纳米肿瘤中心的意图是开发临床上有用的 平台也通过来自UCSD癌症中心的临床医生和 来自大型公司（通用电气，霍尼韦尔，纳米，企业）的参与者将参加 评估研究。