Center of Nanotechnology for Treatment, Understanding, *

纳米技术治疗、理解中心，*

• 批准号: 7688313
• 负责人: SADIK ESENER
• 金额: $ 12.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688313
• 关键词: Achievement; Address; Biotechnology; California; Cancer Center; Complex; Computing Methodologies; Decision Making; Development; Devices; Diagnosis; Drug Delivery Systems; Engineering; Facility Construction Funding Category; Goals; Image; Immune system; In Situ; Institutes; Lead; Malignant Neoplasms; Marketing; Modeling; Monitor; NCI Center for Cancer Research; Nanotechnology; Participant; Play; Production; Research; Research Personnel; Reticuloendothelial System; Role; Site; System; Technology; Therapeutic; Therapeutic Agents; Universities; base; nanoparticle; nanoscale; nanosensors; novel; programs; response; targeted delivery; therapeutic target; tumor; tumor progression

The Center of Excellence of NANOtechnology for Treatment, Understanding, and Monitoring of Cancer (NANO-TUMOR) has been established to perfect a practical nanotechnology base to diagnose, treat, and monitor cancers. Our goal is the development, of a multi-functional "smart mothership" platform that will: (1) evade the reticuloendothelial system and immune system, while attaching specifically to the tumor and its vasculature; (2) assemble a multi-functional complex at the tumor site; (3) deliver payloads of both nanosensors and therapeutics that are activated in situ. The NANO-TUMOR Center has brought together a team of investigators from the University of California, San Diego, Santa Barbara, Irvine, and Riverside campuses, the Burnham Institute and NanoBioNexus. The NANO-TUMOR Center research program is comprised of six interacting projects, each utilizing newly developed and unique technologies that when integrated together will lead to the realization of our goal. The six projects focus on (1) the production of tumor-targeted, non-toxic nanoparticles, (2) the development of a nanoporous micro-platform carrying nanosensors, imaging and therapeutic agents, (3) the creation of tumor-directed amplification systems for sensing and drug delivery, (4) the construction of devices for tumor molecule purification and characterization at a nanoscale level, (5) the application of new computational methods for longitudinal monitoring and analyses of tumor progression and response to therapy, and (6) the in situ assembly and delivery of targeted therapeutics with a smart nanotechnology platform. The Center has been organized using a novel, engineering-type decision and workflow model: Multiple approaches have been proposed to address each project, with go/no go decisions made based on achievement of milestones. The NANOTUMOR project leaders have previously founded more than 20 successful biotechnology companies, with a total market value of over two billion dollars, evidence of their ability to move discoveries to useful applications in the marketplace. The intent of the NANO-TUMOR Center to develop clinically useful platforms is also demonstrated by the strategic role that clinicians from the UCSD Cancer Center, and participants from major corporations (General Electric, Honeywell, Nanogen, Enterprise) will play in evaluating the research.

已经建立了用于治疗，理解和监测纳米技术的卓越中心（纳米肿瘤），以完善实用的纳米技术基础，以诊断，治疗和监测癌症。我们的目标是一个多功能“智能母舰”平台的发展：（1）逃避网状内皮系统和免疫系统，同时特别依附于肿瘤及其脉管系统； （2）在肿瘤部位组装多功能复合物； （3）提供原位激活的纳米传感器和治疗剂的有效载荷。纳米肿瘤中心将来自加利福尼亚大学，圣地亚哥分校，圣塔芭芭拉，尔湾和河滨校园的调查人员团队汇集在一起​​，伯纳姆学院和纳米诺克西斯。纳米肿瘤中心研究计划由六个互动项目组成，每个项目都利用新开发和独特的技术，这些技术将整合在一起，将导致我们的目标实现。这六个项目的重点是（1）靶向肿瘤的无毒纳米颗粒的产生，（2）开发携带纳米传感器的纳米孔微平台，成像和治疗剂，（（3）创建肿瘤指导的扩增系统的传感和药物构造（4）（4）（4）（4）（4）（4）（4）（4）（4）（4）（4）（4）（4）（4）用于纵向监测和对治疗反应的纵向监测和分析的新计算方法，以及（6）具有智能纳米技术平台的原位组装和靶向疗法的原位组装和传递。该中心是使用小说，工程类型的决策和工作流模型组织的：已经提出了多种方法来解决每个项目，并根据基于里程碑的成就做出了go/no go决定。纳米量项目领导者以前已经成立了20多家成功的生物技术公司，总市场价值超过20亿美元，证明了他们将发现转移到市场上有用应用的能力。纳米肿瘤中心开发临床上有用平台的意图也证明了UCSD癌症中心的临床医生以及主要公司（General Electric，Honeywell，Nananogen，Enterprise）的参与者的战略作用，将在评估研究中发挥作用。