A Residential Dust Control Intervention to Reduce Early Childhood Exposure toChemical Mixtures

住宅灰尘控制干预措施，以减少幼儿接触化学混合物

• 批准号: 10662226
• 负责人: Joseph M Braun
• 金额: $ 16.2万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-08 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10662226
• 关键词: 3 year old; Adult; Age; Asthma; Behavior; Biological Markers; Biometry; Birth; Body Burden; Chemical Exposure; Child; Child Health; Child Welfare; Childhood; Childhood Injury; Cognitive; Cohort Studies; Consensus; Data; Development; Disease; Dust; Electronics; Endocrine Disruptors; Environment; Environmental Health; Epidemiology; Ethnic Origin; Exposure to; Family; Flame Retardants; Foundations; Future; Goals; Hand; Health; Home; House Dust; Hypersensitivity; Individual; Intervention; Intervention Studies; Knowledge; Life; Link; Measures; Mediating; Obesity; Ohio; Oral cavity; Organophosphates; Outcome; Parents; Pathway interactions; Policies; Poly-fluoroalkyl substances; Population; Pregnant Women; Problem behavior; Race; Randomized; Randomized, Controlled Trials; Recommendation; Rhode Island; Sampling; Serum; Source; Techniques; Time; building materials; critical period; design; disability; early childhood; effective intervention; evidence based guidelines; exposure pathway; health data; improved; injury prevention; lead exposure; personal care products; phthalates; polybrominated diphenyl ether; preventive intervention; residence; sex; therapy design; trial design; trial enrollment; urinary

Abstract Exposure to endocrine disrupting chemicals (EDCs) during critical periods of development are linked to adverse child health outcomes, including asthma/allergies, behavior problems, IQ decrements, and obesity. Phthalates, flame retardants, and perfluoroalkyl substances (PFAS) are EDCs found in residential dust due to their use in home furnishings, building materials, electronics, and personal care products. Children are exposed to these EDCs as a mixture over the first years of life, often at higher levels than adults. Despite growing consensus that EDC exposures must be reduced, we lack effective interventions to decrease children’s exposure to EDC mixtures in their homes, where they spend the majority of their time. Thus, it is imperative to quantify the contribution of EDC mixtures in residential dust to children’s EDC mixture body burden and determine if interventions that reduce residential dust EDC mixtures effectively diminish childhood exposure to EDC mixtures. We will address this gap in knowledge using data from the Health Outcomes and Measures of the Environment (HOME) Study, a previously conducted randomized controlled trial that enrolled pregnant women from Cincinnati, Ohio and followed their children until age 3 years. We repeatedly collected biospecimens, residential dust samples, and other data from ~200 children ages 1 to 3 years. Using these existing data, we will: (1) Estimate the extent that exposure to EDC mixtures in residential dust is related to children’s EDC mixture body burden; (2) Determine if an intervention designed to reduce residential dust can lower children’s EDC mixture body burden; and (3) Quantify the extent that EDC mixtures in residential dust mediate the relation between an intervention designed to lower residential dust and children’s EDC mixture body burden. Moreover, we will determine if these associations differ by child sex, race/ethnicity, hand-to- mouth behavior, residence type (single vs. multi-family), and residential cleanliness. This solutions-oriented proposal includes experts in EDCs, epidemiology, biostatistics, intervention studies, and children’s environmental health. Together, we will efficiently determine if residential dust control can decrease children’s exposure to EDC mixtures. These results will serve as a basis to design a randomized controlled trial to reduce exposure to EDC mixtures using an ongoing cohort study in Rhode Island. In the absence of population-level interventions to mitigate children’s EDC exposure, our study may provide families and clinicians with evidence- based recommendations about the efficacy of residential dust control to reduce exposure EDC mixtures.

抽象的 在发育关键时期接触内分泌干扰化学物质（EDC）与 不良的儿童健康结果，包括哮喘/过敏、行为问题、智商下降和肥胖。 邻苯二甲酸盐、阻燃剂和全氟烷基物质 (PFAS) 是住宅灰尘中发现的 EDC，原因如下： 它们在家居用品、建筑材料、电子产品和个人护理产品中的应用是儿童。 在生命的最初几年里，他们接触这些 EDC 的混合物，其水平通常高于成年人。 越来越多的人认为必须减少 EDC 暴露，但我们缺乏有效的干预措施来减少 儿童在家里接触 EDC 混合物，他们大部分时间都呆在家里。 量化住宅灰尘中的 EDC 混合物对儿童 EDC 混合物体的贡献势在必行 负担并确定减少住宅灰尘 EDC 混合物的干预措施是否能有效减少童年 我们将使用健康结果和 EDC 混合物的数据来解决这一知识差距。 环境措施（HOME）研究，一项先前进行的随机对照试验，招募了 我们反复收集来自俄亥俄州辛辛那提的孕妇并跟踪她们的孩子直到 3 岁。 生物样本、住宅灰尘样本以及来自约 200 名 1 至 3 岁儿童的其他数据。 根据现有数据，我们将： (1) 估计暴露于住宅灰尘中的 EDC 混合物与以下因素相关的程度： (2) 确定旨在减少住宅灰尘的干预措施是否可以 降低儿童 EDC 混合物的身体负担；以及 (3) 量化住宅灰尘中 EDC 混合物的程度 调解旨在降低住宅灰尘的干预措施与儿童 EDC 混合物之间的关系 此外，我们将确定这些关联是否因儿童性别、种族/民族、手向而异。 口腔行为、住宅类型（单户住宅与多户住宅）以及住宅清洁度。 提案包括 EDC、流行病学、生物统计学、干预研究和儿童问题方面的专家 我们将共同有效地确定住宅灰尘控制是否可以减少儿童的健康。 这些结果将作为设计随机对照试验以减少接触 EDC 混合物的基础。 在罗德岛州进行的一项队列研究中，在缺乏人口水平的情况下，暴露于 EDC 混合物。 减少儿童接触 EDC 的干预措施，我们的研究可以为家庭和维权者提供证据- 基于住宅灰尘控制功效以减少接触 EDC 混合物的建议。