Prospective Study of Restless Leg Syndrome

不宁腿综合症的前瞻性研究

• 批准号: 7788241
• 负责人: Xiang Gao
• 金额: $ 32.63万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7788241
• 关键词: Address; Adult; Affect; Age; Applications Grants; Biological Markers; Blood; Blood Donations; Body mass index; Brain; Cardiovascular Diseases; Characteristics; Chronic; Chronic Disease; Clinical; Cohort Studies; Coronary heart disease; DNA; Diagnosis; Diet; Dietary Practices; Dietary intake; Documentation; Dopamine; Dopamine D2 Receptor; Dose; Environmental Risk Factor; Epidemiologic Studies; Erectile dysfunction; Etiology; Female; Follow-Up Studies; Functional disorder; Future; General Population; Genes; Genetic; Genetic Polymorphism; Habits; Health; Health Occupations; Health Professional; High Prevalence; Hip region structure; Hormones; Hypertension; Individual; International; Investigation; Iron; Knowledge; Lead; Leg; Life Style; Link; MEIS1 gene; Medical History; Methods; Movement Disorders; Neuraxis; Nurses' Health Study; Obesity; Outcome; Parkinson Disease; Participant; Pathogenesis; Patients; Postmenopause; Prevention; Principal Investigator; Prospective Studies; Public Health; Publishing; Quality of life; Registered nurse; Reporting; Reproductive History; Research; Restless Legs Syndrome; Risk; Risk Factors; Role; Sampling; Series; Severities; Sleep; Smoke; Smoking; Stroke; Subgroup; Susceptibility Gene; Syndrome; System; Testing; Time; Tyrosine 3-Monooxygenase; Weight Gain; Woman; aged; base; cofactor; cohort; cost; design; disease natural history; disorder risk; emerging adult; follow-up; genetic risk factor; genome wide association study; health related quality of life; high risk; improved; lifestyle factors; male; male health; men; middle age; mortality; novel strategies; obesity risk; older men; population based; prospective; public health relevance; response; waist circumference

DESCRIPTION (provided by principal investigator): The restless legs syndrome (RLS) is a common movement disorder, characterized by an almost irresistible urge to move the legs. According to recent estimates, it affects 5-20 percent of adults and often has a substantial impact on sleep, daily activities and quality of life. However, the etiology of RLS remains unknown. Large, well-characterized cohort studies with validated assessment of lifestyle factors could provide critical information and lead to new approaches for prevention and treatment. Particularly, there is a need of further large prospective studies on the clinical impact of RLS given a high prevalence of the syndrome. Because the majority of RLS patients (~90 percent) remain undiagnosed, studies based on clinical series may not adequately represent the spectrum and natural history of the disease. Some studies, primarily cross-sectional, found that RLS patients had a higher prevalence of a number of chronic diseases (e.g., cardiovascular disease and Parkinson's disease), and an increased risk of mortality. We propose here to document the occurrence of RLS among female and male participants of two large and well established cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study II (NHS II), for the purpose of addressing several important hypotheses related to the etiology and clinical impacts of RLS. The HPFS and NHS II were initiated in 1986 and 1989 respectively, including 51,529 male health professionals (aged 45-70 in 1986) and 116,678 middle-aged female registered nurses (aged 25-42 in 1989). Information of RLS, using standardized questions, has been collected since 2002 in the HPFS and 2005 in the NHS II. We will investigate 1) whether blood donation, obesity, genetic components are associated with RLS risk during 4-6 years of follow-up; and 2) whether RLS is associated with an increased risk of chronic diseases (coronary heart disease, stroke, hypertension, Parkinson's disease and erectile dysfunction) and mortality in the HPFS (2002-2010) and the NHS II (2005-2011). We expect to be able to document 5167 prevalent and 935 incident RLS cases, which will provide unprecedented power to test the proposed hypotheses. In addition, documentation of the occurrence of RLS in our cohorts is the critical component of a large bank of information that includes multiple and validated assessments of several aspects of lifestyle, including diet and health habits, over a period of 16 years in men and women, and prospectively collected blood and DNA samples. This bank of information is unique and will be of significance for future investigations on RLS and biomarkers and genetic characteristics. PUBLIC HEALTH RELEVANCE: The primary aim of this application is to examine whether blood donation, obesity and genetic components influence risk of restless legs syndrome and whether restless legs syndrome increases risk of chronic diseases and mortality.

描述（由主要研究人员提供）：不安的腿综合征（RLS）是一种常见的运动障碍，其特征是几乎无法抗拒移动腿部。根据最近的估计，它影响了5-20％的成年人，并且经常会对睡眠，日常活动和生活质量产生重大影响。但是，RLS的病因仍然未知。对生活方式因素进行验证的大型，良好的队列研究可能会提供关键信息，并导致预防和治疗的新方法。特别是，鉴于综合征的高患病率，需要对RLS的临床影响进行进一步的大量前瞻性研究。由于大多数RLS患者（约90％）仍未诊断，因此基于临床系列的研究可能不能充分代表该疾病的频谱和自然病史。一些研究主要是横断面的研究，发现RLS患者的多种慢性疾病（例如心血管疾病和帕金森氏病）的患病率更高，死亡风险增加。我们在这里提议记录两个大型且良好的同伙，卫生专业人员随访研究（HPFS）和护士健康研究II（NHS II）的RLS的发生，目的是解决与RLS的病因和临床影响有关的几个重要假设。 HPF和NHS II分别于1986年和1989年启动，其中包括51,529名男性卫生专业人员（1986年45-70岁）和116,678名中年女性注册护士（1989年25-42岁）。自2002年以来，使用标准化问题的RLS信息已收集在HPFS和2005年的NHS II中。我们将研究1）在4 - 6年的随访期间，血液捐赠，肥胖，遗传成分与RLS风险有关； 2）RLS是否与HPFS（2002-2010）和NHS II（20055-2011）中慢性疾病（冠心病，中风，高血压，帕金森氏病和勃起功能障碍）的风险增加有关。我们希望能够记录5167个普遍存在和935例RLS案例，这将提供前所未有的能力来检验拟议的假设。此外，在我们的队列中，RLS发生的记录是一大批信息的关键组成部分，其中包括对生活方式的多个方面的多个和经过验证的评估，包括饮食和健康习惯，在男性和女性中有16年的时间，以及前瞻性收集的血液和DNA样品。该信息库是独一无二的，对于未来对RLS和生物标志物以及遗传特征的研究将具有重要意义。 公共卫生相关性：该应用的主要目的是检查血液捐赠，肥胖和遗传成分是否会影响腿部不安综合征的风险，以及躁动不安的腿综合症是否会增加慢性疾病和死亡率的风险。