Parental Influences on Emotion Regulation Pathways Among Youth with and without ADHD

父母对患有和不患有多动症的青少年情绪调节途径的影响

基本信息

批准号：
10535914
负责人：
Kathleen E Feeney
金额：
$ 3.75万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-17 至 2024-09-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10535914
关键词：
Address Adolescent Affective Age Amygdaloid structure Attention Attention deficit hyperactivity disorder Behavior Behavioral Brain Child Child Behavior Checklist Child Development Child Rearing Childhood Cognition Disorders Cognitive Communication Communities Conflict (Psychology)Data Data Analyses Data Set Development Disease Emotional Emotions Family Foundations Functional Magnetic Resonance Imaging Goals Gold Heterogeneity Impairment Influentials Interview Lead Literature Measures Mediating Methods Monitor Network-based Neuraxis Neurodevelopmental Disorder Outcome Parents Participant Pathway interactions Population Prefrontal Cortex Protocols documentation Psychopathology Psychophysiology Reporting Research Research Activity Research Personnel Rest Risk Risk Behaviors Role Sample Size Sampling Science Site Social outcome Structure Supervision System Training Training Activity Variant Work Youth aged base brain behavior career clinical care clinical diagnostics clinical heterogeneity cognitive control cognitive development cognitive function data acquisition design emotion dysregulation emotion regulation emotional functioning functional MRI scan functional outcomes improved neurodevelopment parental influence parental monitoring peer programs resilience sex skill acquisition social systematic review theories

项目摘要

Project Summary/Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder (i.e., 11% of youth). Traditionally, ADHD has been conceptualized as a disorder of cognitive functioning; however, work by the applicant and others has emphasized the need to assess emotional functioning in order to better conceptualize the disorder and tailor clinical care. Emotion dysregulation is a transdiagnostic factor that is often present among youth with ADHD and can lead to poor academic, functional, and social outcomes. Importantly, specific parental factors may serve as mechanisms of risk or resilience in the development of child emotion regulation in ADHD. However, parental influences on child brain-behavior associations remain understudied in this population. Thus, a multi-method approach is necessary to determine mechanisms that lead to the development of emotion dysregulation and to identify the most at-risk youth. The primary goal of the proposed research and training activities are to develop an independent program of research examining the influence of parental factors on emotion regulation among youth with ADHD. Assessment of emotion dysregulation will be conducted via behavioral report and resting-state functional connectivity between the amygdala and cortical networks encompassing regions within the prefrontal cortex. The applicant is already well-versed in behavioral and psychophysiological analysis of emotion regulation in ADHD, and has completed introductory training on use of ABCD data. Thus, the proposed training plan highlights skill development in: 1) child neurodevelopment and psychopathology, 2) fMRI data acquisition and design, 3) rs fMRI data analysis and interpretation, and 4) professional development related to effective science communication. The proposed study seeks to examine the effects of parental factors (e.g., poor monitoring/supervision, high conflict) on emotion regulatory systems (i.e., behavioral, central nervous system). As part of the ABCD study, approximately 12,000 child participants (an estimated 1,300 with ADHD; aged 9-10 years) completed behavioral reports of parental monitoring/supervision and underwent an fMRI scan protocol during which resting-state functional connectivity was measured. Parents completed a diagnostic clinical interview and reported on family conflict and child dysregulation. This data will allow the applicant to address two primary aims: 1) Examine associations between parental factors and child dysregulation among youth with and without ADHD, and 2) Examine associations between parental factors, child resting-state functional connectivity, and child dysregulation among youth with and without ADHD. The ultimate goal of this work will be to improve characterization of ADHD, to identify potential treatment targets for the most at-risk youth, and to set the stage for longitudinal work on child brain development as it relates to emotional functioning and functional outcomes. These training and research goals will support the development of PI Feeney in obtaining a career as an independent researcher focused on parental influences on child brain development specific to emotion dysregulation.

项目概要/摘要注意力缺陷/多动障碍 (ADHD) 是最常见的神经发育障碍（即 11% 青年）。传统上，多动症被概念化为一种认知功能障碍。然而，工作申请人和其他人强调需要评估情绪功能，以便更好地概念化疾病并定制临床护理。情绪失调是一个跨诊断因素，经常被存在于患有多动症的青少年中，并可能导致学业、功能和社会结果不佳。重要的是，特定的父母因素可能作为儿童情绪发展的风险或复原力机制 ADHD 的调节。然而，父母对儿童大脑行为关联的影响仍未得到充分研究。这个人口。因此，有必要采用多种方法来确定导致情绪失调的发展并确定最危险的青少年。拟议的主要目标研究和培训活动的目的是制定一个独立的研究计划，审查以下因素的影响：父母因素对多动症青少年情绪调节的影响。情绪失调的评估将通过行为报告和杏仁核和皮质之间的静息状态功能连接进行网络涵盖前额皮质内的区域。申请人已经精通行为学和多动症情绪调节的心理生理学分析，并完成了入门培训 ABCD 数据的使用。因此，拟议的培训计划强调以下方面的技能发展：1）儿童神经发育和精神病理学，2) fMRI 数据采集和设计，3) rs fMRI 数据分析和解释，以及 4) 与有效的科学传播相关的专业发展。拟议的研究旨在检验父母因素（例如，不良监控/监督、高度冲突）对情绪调节系统的影响（即行为、中枢神经系统）。作为 ABCD 研究的一部分，大约 12,000 名儿童参与者（估计有 1,300 名多动症患者；年龄 9-10 岁）完成了父母的行为报告监测/监督并接受功能磁共振成像扫描协议，在此期间静息态功能连接被测量。父母完成了诊断性临床访谈并报告了家庭冲突和孩子的情况失调。该数据将使申请人能够解决两个主要目标：1）检查之间的关联患有和不患有多动症的青少年中的父母因素和儿童失调，以及 2) 检查关联父母因素、儿童静息状态功能连接和青少年儿童失调之间的关系并且没有多动症。这项工作的最终目标是改善 ADHD 的特征，识别针对高危青少年的潜在治疗目标，并为儿童大脑的纵向研究奠定基础发展与情绪功能和功能结果有关。这些培训和研究目标将支持 PI Feeney 的发展，使其成为一名独立研究员，专注于父母对儿童大脑发育的影响，特别是情绪失调。