Low Ignition Propensity (LIP) Study

低点火倾向 (LIP) 研究

• 批准号: 7701335
• 金额: $ 7.6万
• 依托单位: NATIONAL CANCER INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7701335
• 关键词: Low; Ignition; Propensity; LIP; Study

PURPOSE: The purpose of this study is to examine the impact of low ignition propensity (LIP) cigarette laws in New York State and Canada on fire incidence, smoking behaviors, smoke toxin exposure and cigarette design. A. BACKGROUND The Low Ignition Propensity (LIP) cigarette law went into effect in New York on June 28, 2004, and the Canadian law became effective as of October 1, 2005. Both require that all cigarettes be certified using the American Society of Testing and Materials (ASTM) test for ignition propensity. The purpose of these laws is to reduce the incidence of cigarette-caused fires, which caused 10,130 deaths and 29,296 injuries in the US and 1,139 deaths and 3,376 injuries in Canada between 1990 and 1999. LIP laws could have important implications for toxin exposure since change in the cigarette design would be required to reach the new ignition propensity certification. Research on the efficacy and related impacts of this harm reduction policy can inform legislators considering similar laws. B. STATEMENT OF WORK and/or DESCRIPTION OF SERVICES This study will examine the smoking topography and toxin exposures of 60 smokers each in NY, MA, and ON to determine if LIP cigarettes alter smoking behavior or exposure to smoke toxins (CO, NNAL, PAHs). Smokers of specific brands will smoke their usual brand over a period of two weeks. Smokers will come to the laboratory on two occasions to provide saliva and urine samples. Smokers will be provided a CReSSmicro device, and smoke at least 5 cigarettes per day using the device over the course of two days. Salivary samples will be assayed for cotinine. Urine samples will be assayed for carcinogen metabolites (1-hydroxypyrene [1-HOP], 1-naphthol, 2-naphthol, and NNAL). Smokers will keep a diary reporting cigarettes smoked per day and will be asked to retain cigarette butts from the day preceding each laboratory visit. CDC/NCEH/DLS will provide expertise in sample collection procedures and analysis of biomarkers in biological specimens. CDC will measure hydroxylated PAH metabolites (N=20 including metabolites of Naphthalene, Fluorene, Phenanthrene, Pyrene, Benzo(c)phenanthrene, Benzo(a)anthracene and Chrysene) up to 360 urine samples. C. PERIOD OF PERFORMANCE The period of performance for this IAA is from the date of final signature through September 20, 2008. The term of performance for the project funded by this IAA shall be from February 20, 2008 through December 31, 2009. Results will be reported no later than 180 days upon receipt of samples. Samples are expected to be shipped to NCEH in March 2008. NIH shall collect and process urine specimens for the proposed laboratory assessments and will batch-ship frozen samples at an agreed-upon date to DLS via Federal Express or similar express carrier in accordance with all applicable biohazard, shipping, and CDC rules in March 2008. NCEH, upon receipt of the samples indicated above, shall do all necessary sample preparation and analysis. NCEH will be responsible for storing the urine specimens in -70oC freezers until samples are returned to NIH/NCI or discarded. D. REPORTING REQUIREMENTS NCEH/DLS will provide NIH/NCI with electronic data files of the results and the methods used for analysis of the specimens. Data will be reported no later than 180 following receipt on samples.

目的：这项研究的目的是检查纽约州和加拿大低点火倾向（LIP）香烟法对火灾发生率，吸烟行为，烟雾毒素暴露和香烟设计的影响。 A.背景 低点火倾向（LIP）卷烟法于2004年6月28日在纽约生效，并于2005年10月1日生效。两者都要求使用美国测试和材料协会（ASTM）测试对所有香烟进行认证。这些法律的目的是减少引起的香烟引起的大火的发病率，在美国造成10,130例死亡和29,296人的伤害，1,139人的死亡和1990年1999年加拿大的1,139人死亡和3,376人受伤。在加拿大之间，LIP法律之间可能需要对烟烟设计的变化，因此对毒to造成了重要的影响。对这种减少危害政策的疗效和相关影响的研究可以告知立法者考虑类似法律。 B.工作声明和/或服务说明 这项研究将检查纽约州纽约州60名吸烟者的吸烟地形和毒素暴露，以确定唇彩是否改变了吸烟行为或暴露于烟毒素（CO，Nalnal，PAHS）。 特定品牌的吸烟者将在两个星期的时间内吸烟其通常的品牌。吸烟者将两次来到实验室提供唾液和尿液样本。在两天的时间里，将为吸烟者提供一种Cressmicro设备，每天使用该装置至少吸烟。唾液样品将用于可替宁。尿液样品将用于致癌代谢产物（1-羟基苯乙烯[1-HOP]，1-萘酚，2-萘酚和NNAL）。吸烟者将保留一份日记，报告每天抽烟，并要求从每次实验室访问前一天起保留烟头。 CDC/NCEH/DLS将在样品收集程序和生物标本中的生物标志物分析方面提供专业知识。 CDC将测量羟基化的PAH代谢产物（n = 20，包括萘，氟，苯the鸟，pyrene，pyrene，benzo（c）苯than烯，苯甲酸苯甲酸苯酚（a）蒽和金烯烯）的代谢产物，高达360个尿液样品。 C.性能期 该IAA的性能期限为从最终签名到2008年9月20日。该IAA资助的项目的绩效期限应为2008年2月20日至2009年12月31日。结果将在收到样品后的180天内不迟于180天。 预计样品将于2008年3月运送到NCEH。NIH应收集和处理拟议的实验室评估的尿液标本，并将在同意的日期通过联邦Express或类似的Express Carrier批准冻结样品，并根据所有适用的Biiohazard，运输，以及2008年3月的CDC规则。 NCEH，收到上述样品后，应进行所有必要的样品制备和分析。 NCEH将负责将尿液样本存储在-70oc冰柜中，直到将样品返回到NIH/NCI或丢弃。 D.报告要求 NCEH/DLS将为NIH/NCI提供结果的电子数据文件以及用于分析样品的方法。在收到样品后，数据将不晚于180。