STATISTICAL AND DATA MANAGEMENT CORE

统计和数据管理核心

• 批准号: 7350360
• 负责人: Sue E. Leurgans
• 金额: $ 24.73万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7350360
• 关键词: Alzheimer' s Disease; Brain region; Clinical; Clinical Data; Data; Data Analyses; Data Collection; Data Linkages; Data Set; Databases; Diagnosis; Elderly; Goals; Impaired cognition; Laboratories; Libraries; Link; Measures; Molecular; Neurobiology; Program Research Project Grants; Religion and Spirituality; Research; Research Design; Research Personnel; Resources; Site; Specific qualifier value; case-based; data management; experience; genetic linkage analysis; mild neurocognitive impairment; neuropathology; programs; statistics

The proposed Statistics and Data Management Core for the Program Project will provide the computational and analytic resources for successful data collection, storage, linkage, and analysis for all projects in the Program Project. The proposed core will have a data management component and a statistical analysis component. The proposed core will have both data management portion of the core include: 1) linking existing data from Religious Order Study and the Rush Alzheimer's Disease Core Center with findings from the four proposed projects and 2) providing statistical support for all of the studies carried out by the projects. The statistical responsibilities of the core will include providing advice on study design and statistical programming, and providing methodologic expertise on specific questions arising from the use of multiple measures of cognitive impairment. The research goals of the Program Project present complexities and challenges both in the management and in the analysis of the data. Data management will be complicated because of the large quantity of data in varied formats from separate sites, the multiplicity of variables collected from multiple brain regions and multiple studies within one core. This Core will provide expert support from a statistical research team experienced in the conduct of neuropathological studies.

该计划项目的拟议统计和数据管理核心将提供计算 以及用于成功收集数据，存储，链接和分析的分析资源 计划项目。所提出的核心将具有数据管理组件和统计分析 成分。所提出的核心将具有核心的两个数据管理部分包括：1）链接 宗教秩序研究和拉什阿尔茨海默氏病核心中心的现有数据以及来自 提议的四个项目和2）为所有研究提供统计支持 项目。核心的统计责任将包括提供有关研究设计的建议和 统计编程，并提供有关使用的特定问题的方法论专业知识 多种认知障碍的措施。 该计划项目的研究目标提出了管理中的复杂性和挑战 并在数据分析中。数据管理将变得复杂，因为大量数据 以不同地点的各种格式，从多个大脑区域收集的多样性和 一个核心内的多次研究。该核心将提供统计研究团队的专家支持 在神经病理学研究的进行方面经验丰富。