Concept Project

概念项目

• 批准号: 7681733
• 负责人: BRYON H. ADINOFF
• 金额: $ 125万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7681733
• 关键词: Adolescent; Alcohol or Other Drugs use; Algorithms; Attention deficit hyperactivity disorder; Classification; Clinical; Communities; Condition; Decision Making; Decision Trees; Disease; Drug usage; Frequencies; Knowledge; Major Depressive Disorder; Mental disorders; Outcome; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Quality of life; Randomized; Research; Substance Use Disorder; Therapeutic; addiction; base; concept; experience; improved; user-friendly

The aim of this proposal is to determine whether the treatment of co-occurring psychiatric disorder(s) will improve the outcomes of substance use (e.g., frequency of drug use, quality of life) when combined with substance-related treatment that is normally provided to adolescents in community addiction treatment settings. In addition, this study will determine whether the systematic treatment of attention-deficit hyperactivity disorder (ADHD) and/or major depressive disorder (MDD) will result in greater symptomatic improvement of the targeted disorder(s) compared with treatment as usual (TAU). ADHD and MDD will be targeted because these two conditions frequently co-occur with substance use disorders (SUD) in adolescents, and evidence-based, efficacious pharmacological treatments for each disorder are available for clinical use.Adolescents with SUD who also have ADHD and/or MDD will be randomized to receive either TAU or TAU in conjunction with systematic treatment for ADHD and/or MDD. The treatment of ADHD and/or MDD will be based on medication algorithms that facilitate a systematic approach for therapeutic decision-making, and thereby decrease the variance in treatment approaches and enhance patient outcomes. The algorithms are based on integrated knowledge of research information and clinical experience. Thus, they can be used both in research and clinical practice. They are user-friendly and offer step-by-step medication decision trees as well as procedural details for implementation.

该提案的目的是确定同时发生的精神疾病的治疗是否会改善药物使用结果（例如，药物使用频率，生活质量，生活质量）与通常提供给社区成瘾治疗环境中青少年的物质相关治疗。此外，这项研究将确定注意力缺陷多动症（ADHD）的系统治疗和/或主要抑郁症 与往常一样，疾病（MDD）将导致靶向疾病的症状改善更大（tau）。 ADHD和MDD将被针对目标，因为这两种情况经常与青少年的药物使用障碍（SUD）共发生，并且针对每种疾病的循证，有效的药理治疗是 可用于临床使用。患有ADHD和/或MDD的SUD的Adectents将随机分配以与ADHD和/或MDD的系统处理结合使用Tau或Tau。多动症和/或MDD的处理将基于促进系统性决策方法的药物算法，从而减少治疗方法的差异并增强患者的预后。该算法基于研究信息和临床经验的综合知识。因此，它们可以在研究和临床实践中使用。它们是用户友好的，并逐步提供 药物决策树以及实施的程序细节。