Determination of the site of pharyngeal collapse in Obstructive Sleep Apnea patients from snoring sounds

从鼾声判断阻塞性睡眠呼吸暂停患者咽部塌陷部位

• 批准号: 10515474
• 负责人: DAVID ANDREW WELLMAN
• 金额: $ 59.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10515474
• 关键词: Acoustics; Address; Adherence; Algorithms; Clinical; Continuous Positive Airway Pressure; Data; Data Collection; Data Set; Devices; Disease; Drug usage; Early identification; Endoscopy; Epiglottis structure; Explosion; Goals; Grant; Health; Home; Home environment; Hypoglossal nerve structure; Individual; Label; Lateral; Literature; Mandibular Advancement; Measurement; Measures; Methods; Mission; National Heart, Lung, and Blood Institute; Obstruction; Obstructive Sleep Apnea; Operative Surgical Procedures; Oropharyngeal; Otolaryngologist; Outcome; Patient Selection; Patients; Persons; Pharmaceutical Preparations; Pharyngeal structure; Problem Solving; Procedures; Progress Reports; Public Health; Reproducibility; Research; Shapes; Signal Transduction; Site; Sleep; Sleep Disorders; Snoring; Structure; Testing; Therapeutic; United States National Institutes of Health; Work; base; clinical practice; cost; effective therapy; experimental study; improved; predictive modeling; public repository; sound; tongue root

ABSTRACT Obstructive Sleep Apnea (OSA) is a prevalent disorder that remains undertreated due to poor adherence with continuous positive airway pressure (CPAP). Several studies suggest that the pharyngeal airway can collapse at different sites in patients with OSA (velum, oropharyngeal lateral walls, tongue base, and/or epiglottis). Furthermore, many of the non-CPAP treatments for OSA have been shown to work better for some sites of collapse than others. The problem is, the site of collapse requires expensive or invasive procedures, such as drug-induced sleep endoscopy (DISE). This proposal seeks to solve that problem by determining the site of collapse from acoustic analysis of snoring sounds. In Aim 1, a model for predicting the site of collapse will be developed using DISE with simultaneously measured snoring sounds in 800 individuals. In Aim 2, natural sleep endoscopy will be performed in a subset of people from Aim 1 to confirm that the collapsing structure(s) produce the same sound in natural sleep as drug-induced sleep. Finally, Aim 3 will test the ability to measure snoring sounds in the home environment. Comparisons will be made between snores from natural sleep endoscopy and natural sleep at home (in the same individual). Additionally, snoring will be measured at home on separate nights to test reproducibility across nights. The studies in this grant are expected to produce an algorithm for estimating the site of pharyngeal collapse from snoring sounds. This algorithm could improve the selection of patients for non-CPAP therapies and potentially increase the number of patients effectively treated for OSA.

抽象的 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的疾病，由于缺乏良好的治疗措施，该疾病仍未得到充分治疗。 坚持持续气道正压通气（CPAP）。多项研究表明咽部 OSA 患者的气道可能在不同部位塌陷（软腭、口咽侧壁、舌根、 和/或会厌）。此外，许多治疗 OSA 的非 CPAP 治疗方法已被证明对治疗 OSA 效果更好。 一些地点的倒塌程度高于其他地点。问题是，塌陷现场需要昂贵的或侵入性的 程序，例如药物诱导睡眠内窥镜检查 (DISE)。该提案旨在通过以下方式解决该问题 通过对鼾声的声学分析来确定倒塌部位。 在目标 1 中，将使用 DISE 开发一个预测倒塌地点的模型，同时 测量了 800 人的打鼾声音。在目标 2 中，将在一个子集中进行自然睡眠内窥镜检查 来自目标 1 的人确认倒塌的结构在自然睡眠中产生与 药物引起的睡眠。最后，Aim 3 将测试测量家庭环境中打鼾声音的能力。 将比较自然睡眠内窥镜检查和在家自然睡眠（在 同一个人）。此外，将在不同的夜晚在家中测量打鼾情况，以测试可重复性 跨越夜晚。 这项资助的研究预计将产生一种估计咽部位置的算法 因鼾声而崩溃。该算法可以改善患者对非 CPAP 治疗的选择 并可能增加有效治疗 OSA 的患者数量。