Focusing of Drug-Coated Nano-Particles to Deep Tissue Tumors by Feedback Control

通过反馈控制将药物包被的纳米颗粒聚焦于深部组织肿瘤

• 批准号: 7660095
• 负责人: Andreas S. Luebbe
• 金额: $ 22.43万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7660095
• 关键词: Address; Adverse effects; Anatomy; Animals; Arts; Blood; Blood flow; Body Image; Cells; Chemicals; Clinical; Clinical Trials; Complement; Complex; Computer software; Development; Drug Controls; Drug Delivery Systems; Engineering; Epirubicin; Feedback; Future; Glycerol; Goals; Grant; Human; Laws; Legal patent; Life; Liquid substance; Location; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Methods; Mitoxantrone; Molecular; Patients; Pharmaceutical Preparations; Phase; Research; Rest; Safety; Skin; Surface; Techniques; Technology; Testing; Time; Tissues; Tumor Tissue; Veins; Water; Work; base; cancer therapy; chemotherapy; drug efficacy; ferrofluid; innovation; killings; magnetic field; meetings; nanoparticle; nanoscale; neoplastic cell; particle; public health relevance; research study; sarcoma; scale up; sensor; simulation; tumor; uptake

DESCRIPTION (provided by applicant): In chemotherapy treatment, the level of treatment is usually determined by the level of chemotherapy that the patient can withstand, not the amount that is necessary to kill all tumor cells. We will focus drug-coated magnetic nano-particles to tumors by dynamic control of external magnets, allowing focused (high-concentration) treatment at the tumor with low levels of chemotherapy in the rest of the body. Magnetic nano-particle drug delivery already exists but it is limited to tumors near the skin surface. In this R21 grant we aim to show that it is feasible to precisely control magnetic fields to focus chemotherapy nano-particles to tumors deep inside the body - our goal is to show proof-of-concept. Hence deep-focusing will be experimentally demonstrated in a simple vasculature phantom (as recommended by reviewer 1 in our first submission). PUBLIC HEALTH RELEVANCE: This research would allow targeted chemotherapy. It would allow confinement of drugs at deep tumors with a low concentration of drugs in the rest of the body, thus enabling more effective cancer treatment but reducing life-threatening chemotherapy side effects.

描述（由申请人提供）：在化学疗法治疗中，治疗水平通常取决于患者可以承受的化学疗法水平，而不是杀死所有肿瘤细胞所必需的量。我们将通过动态控制外部磁体的动态控制将药物涂覆的磁性纳米粒子聚焦于肿瘤，从而在体内的肿瘤中进行聚焦（高浓度）治疗，在体内其他部位的化学疗法水平较低。磁性纳米粒子药物递送已经存在，但仅限于皮肤表面附近的肿瘤。在此R21赠款中，我们的目的是表明，精确控制磁场将化学疗法纳米颗粒聚焦到体内深处的肿瘤是可行的 - 我们的目标是显示概念验证。因此，将在简单的脉管系统幻影中实验证明深度关注（如审稿人1在我们的第一次提交中的建议）中。公共卫生相关性：这项研究将允许有针对性的化学疗法。这将允许在体内其余部分的深肿瘤处限制药物，从而使癌症治疗更有效，但会减少威胁生命的化学疗法副作用。