Nutritional Epidemiology of Lower Urinary Tract Symptoms

下尿路症状的营养流行病学

• 批准号: 7737960
• 负责人: Nancy Nairi Maserejian
• 金额: $ 19.63万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7737960
• 关键词: Accounting; Adult; Age; Aging; Alcohol consumption; Area; Ascorbic Acid; Beverages; Boston; Caffeine; Calcium; Carbohydrates; Carbonated Beverages; Carbonates; Carotenoids; Categories; Cholesterol; Cigar; Cigarette; Clinical; Coffee; Cohort Studies; Communities; Community Health; Comorbidity; Confounding Factors (Epidemiology); Data; Data Collection; Data Set; Diabetes Mellitus; Diet; Dietary Assessment; Dietary intake; Diuretics; Dose; Ethnic Origin; Fatty acid glycerol esters; Food; Gender; Health Status; Health Surveys; Heart Diseases; Individual; Intake; Juice; Kidney Diseases; Knowledge; Life Style; Liquid substance; Literature; Macronutrients Nutrition; Malignant Neoplasms; Manuscripts; Methodology; Micronutrients; Minerals; Modeling; Modification; Multivariate Analysis; NIH Program Announcements; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Nutrient; Obesity; Pharmaceutical Preparations; Pharmacologic Substance; Physical activity; Population Heterogeneity; Prevention; Proteins; Publishing; Quality of life; Race; Relative (related person); Research; Research Design; Risk Factors; Role; Sampling; Smoking; Socioeconomic Status; Sodium; Source; Symptoms; Tea; Time; To specify; Tobacco use; Urinary Incontinence; Urination; Variant; Vitamin A; Woman; Zinc; Zinc deficiency; base; community health study; cost; design; energy balance; follow-up; food consumption; innovation; lifestyle factors; lower urinary tract symptoms; men; modifiable risk; nutritional epidemiology; polyunsaturated fat; population based; primary outcome; prospective; public health relevance; response; saturated fat; secondary outcome; trend; urologic

DESCRIPTION (provided by applicant): This project utilizes dietary data that was collected as part of the Boston Area Community Health (BACH) study to help fill knowledge gaps in the nutritional epidemiology of urogynecologic symptoms in a diverse, random community-based sample. Lower urinary tract symptoms (LUTS), including storage, voiding and post micturition symptoms, are a source of daily bother and burden and profoundly lower the quality of life of millions of adults - over 30 million men and women in the US alone. The once prevailing paradigm that these symptoms are an inevitable aspect of aging, unaffected by modification of lifestyle choices, must be challenged, and this study responds to nation-wide calls for research to identify risk factors for these symptoms. One of the most readily modifiable lifestyle factors that holds highly plausible mechanisms of offering relief and prevention, as well as being involved in the initiation and progression, of LUTS is diet - i.e., the nutrients and beverages consumed daily. This study examines the cross-sectional and longitudinal associations between intakes of carbohydrate, protein, types of fat, sodium, cholesterol, vitamin C, vitamin A, carotenoids, calcium and zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, including urgency and urinary incontinence, separately in men and women. It also examines dietary versus supplemental sources of micronutrients and dose-response trends across categories of intake. Intakes of various beverage types are also examined prospectively to verify anecdotal evidence regarding effects of caffeine, acidic or carbonated beverages. BACH obtained a complete validated dietary assessment that takes into account ethnic variation in food consumption, which, together with in-depth data on urologic symptoms, sociodemographics, anthropometrics, health status, medication and supplement usage, provides a unique cost-efficient opportunity to conduct multivariate analyses of the role of nutrients and beverages in urologic symptoms among men and women. PUBLIC HEALTH RELEVANCE: 7. PROJECT NARRATIVE This study will investigate the associations between intakes of macronutrients, micronutrients, fluids and lower urinary tract symptoms in a diverse, population-based sample of men and women using both cross- sectional and prospective cohort study design methodologies. Lower urinary tract symptoms will be examined both overall and also grouped as storage symptoms, including urgency and urinary incontinence, voiding symptoms, and post micturition symptoms.

描述（由申请人提供）：该项目利用了作为波士顿地区社区健康（BACH）研究的一部分收集的饮食数据，以帮助填补多元化，基于社区的样本中尿发病态症状的营养流行病学的知识差距。较低的尿路症状（LUTS），包括存储，排尿和排尿后症状，是每天打扰和负担的来源，并深刻降低了数百万成年人的生活质量 - 仅在美国，就有超过3000万男女。曾经盛行的范式是这些症状是衰老的必然方面，不受生活方式选择的影响，必须挑战，这项研究对全国范围内的呼吁呼吁进行研究以识别这些症状的风险因素。最容易改变的生活方式因素之一是提供救济和预防的高度合理机制，以及参与LUTS的启动和进步的涉及，即每天消费的营养和饮料。这项研究研究了碳水化合物，蛋白质，脂肪，钠，胆固醇，维生素C，维生素A，类胡萝卜素A，类胡萝卜素，钙和锌的摄入量之间的横截面和纵向关联它还检查了摄入量的微量营养素和剂量反应趋势的饮食和补充来源。还对各种饮料类型的摄入量进行了前瞻性检查，以验证有关咖啡因，酸性或碳酸饮料的影响的轶事证据。巴赫获得了一项完整的饮食评估，考虑了粮食消费的种族差异，该评估以及有关泌尿科症状，社会人口统计学，人类学，人类学，健康状况，药物治疗和补充用法的深入数据，提供了一个独特的成本效率机会，可以在营养和葡萄酒中进行多个养分和葡萄酒的角色和男性症状的多相分析。公共卫生相关性：7。项目叙述这项研究将研究大量，微量营养素，液体，流体和较低尿路症状的摄入量，使用横断面和前瞻性队列研究设计方法的不同，基于人群的男性和女性样本。较低的尿路症状将被整体检查，并将其分组为储存症状，包括紧迫性和尿失禁，排尿症状和排尿后症状。