The Intra-renal Oxygenation in CKD as evaluated by BOLD MRI

BOLD MRI 评估 CKD 肾内氧合

基本信息

批准号：
7588686
负责人：
POTTUMARTHI V PRASAD
金额：
$ 22.03万
依托单位：
NORTHSHORE UNIVERSITY HEALTHSYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-17 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7588686
关键词：
Acute Kidney Failure Affect Anemia Animal Model Animals Biological Markers Blood flow Chronic Chronic Kidney Failure Clinical Management Cross-Sectional Studies Data Disease Disease Progression Erythropoietin Evaluation Filtration Glomerular Filtration Rate Hand Hematocrit procedure Human Hyperoxia Hypoxia Intervention Inulin Kidney Literature Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Methods Modeling Monitor Nephrectomy Normal Range Outcome Oxygen Oxygen Consumption Patients Preventive Process Production Ramp Rattus Relative (related person)Renal Blood Flow Renal Mass Renal Plasma Flow Renal Replacement Therapy Renal Tissue Renal function Role Staging Techniques Time Tissues base blood oxygen level dependent design human disease human subject in vivo insight kidney cortex novel public health relevance renal hypoxia theories tissue oxygenation tool

项目摘要

DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) leads to progressive loss of kidney function resulting in damaging consequences to the patient. While a role for altered oxygenation status in CKD has been postulated, there is no evidence relevant to human disease. This is due to the lack of non-invasive methods to assess renal oxygenation in vivo in humans. Also, advanced CKD is commonly associated with anemia and it is believed to be related to reduced or lack of increase in erythropoietin (EPO) production. This in turn is believed to be due to enhanced renal cortical oxygen levels. Blood oxygenation level dependent (BOLD) MRI technique as applied to intra-renal oxygenation has been shown to be sensitive in evaluating renal oxygenation both in rat and human kidneys. Currently there is no other known technique that can be used to monitor renal oxygenation status in human kidneys. Based on this background, this proposal extends the present findings in healthy and hypertensive kidneys in both animals and humans using BOLD MRI to evaluate intra-renal oxygenation in CKD patients. For the first time the technique will be extended to human subjects at different stages of disease progression. A successful outcome of this proposal would allow for the first time to appreciate that the renal oxygenation status in patients with CKD at various stages of disease progression compared to healthy controls. It would also support the use of BOLD MRI measurements as a useful non-invasive tool in the evaluation of patients with CKD. These may motivate evaluation of novel interventions specifically targeting hypoxia and hence should have significant consequences in the clinical management of CKD. PUBLIC HEALTH RELEVANCE: Over 7 million people in the US suffer from chronic kidney disease and about half a million will await kidney replacement therapy. It is believed that the oxygen availability within the kidney may be an important determinant of the progression of disease. This study will utilize a non-invasive method to study the oxygen availability within the human kidneys at various stages of disease progression. This would allow for better understanding of the disease process and in turn allow for developing preventive measures.

描述（由申请人提供）：慢性肾脏疾病（CKD）导致肾功能的逐渐丧失，从而损害患者。虽然已经假定了CKD中氧合状态改变的作用，但没有与人类疾病有关的证据。这是由于缺乏评估人体内肾脏氧合的非侵入性方法。同样，晚期CKD通常与贫血有关，据信与促红细胞生成素（EPO）产生的增加或缺乏增加有关。反过来，这被认为是由于肾脏皮质氧水平增强所致。血液氧合水平依赖性（BOLD）MRI技术应用于肾脏内氧合作用，已证明在评估大鼠和人肾脏的肾脏氧合方面都很敏感。目前，没有其他已知技术可用于监测人肾脏中的肾脏氧合状态。基于此背景，该建议扩展了使用BOLD MRI的动物和人类健康和高血压肾脏中目前的发现，以评估CKD患者的肾脏内氧化。在疾病进展的不同阶段，该技术将首次扩展到人类受试者。该提案的成功结果将使首次理解与健康对照相比，疾病进展的CKD患者的肾脏氧合状态。它还将支持在评估CKD患者中使用大胆的MRI测量作为有用的非侵入性工具。这些可能会激发对专门针对缺氧的新干预措施的评估，因此应在CKD的临床管理中产生重大影响。公共卫生相关性：美国超过700万人患有慢性肾脏疾病，大约有50万人将等待肾脏替代疗法。据认为，肾脏内的氧气可利用性可能是疾病进展的重要决定因素。这项研究将利用一种非侵入性方法来研究疾病进展各个阶段人肾脏内的氧气可用性。这将使人们更好地了解疾病过程，进而可以制定预防措施。