PILOT STUDY OF DBS FOR TREATMENT-REFRACTORY OCD

DBS 治疗难治性强迫症的试点研究

• 批准号: 7950706
• 负责人: HERBERT B WARD
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950706
• 关键词: Adverse effects; Anterior; Behavior Therapy; Bilateral; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Country; Data; Deep Brain Stimulation; Disease; Effectiveness; European; Funding; Goals; Grant; Implanted Electrodes; Institution; Internal Capsule; Intervention; Lead; Left; Limb structure; Obsessive-Compulsive Disorder; Operative Surgical Procedures; Patients; Pilot Projects; Procedures; Qualifying; Quality of life; Refractory; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Safety; Severities; Source; Symptoms; Techniques; United States National Institutes of Health; brain tissue; design; improved; neurosurgery; Adverse effects; Anterior; Behavior Therapy; Bilateral; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Country; Data; Deep Brain Stimulation; Disease; Effectiveness; European; Funding; Goals; Grant; Implanted Electrodes; Institution; Internal Capsule; Intervention; Lead; Left; Limb structure; Obsessive-Compulsive Disorder; Operative Surgical Procedures; Patients; Pilot Projects; Procedures; Qualifying; Quality of life; Refractory; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Safety; Severities; Source; Symptoms; Techniques; United States National Institutes of Health; brain tissue; design; improved; neurosurgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research project is to reduce symptom severity and enhance quality of life for subjects with severe and intractable obsessive-compulsive disorder-OCD. Despite advances in the pharmacological and behavioral therapies, a substantial number of patients fail to improve significantly following years of conventional as well as experimental interventions. For some patients, stereotactic neurosurgery is the only promising option left. The available evidence suggests that these procedures may lead to enduring benefits and relatively few side effects in the majority of OCD patients with intractable disease. However, the effects of these ablative techniques on brain tissue and function are irreversible. A team of European investigators reported positive results in three of four intractable cases of OCD using bilateral deep brain stimulation-DBS of the anterior limb of the internal capsule. Independent confirmation by a qualified psychiatric-neurosurgical team is crucial before it gains more widespread use; there are already indications that numerous centers across the country are pursuing it. Although DBS, like ablative surgery, is an invasive procedure with infrequent but serious risks, unlike ablative techniques, DBS is adjustable and partially reversible. The current project is designed to gather preliminary data on the effectiveness, safety, and tolerability of chronic stimulation-DBS via bilaterally implanted electrodes in the anterior limb of the internal capsules of 6 subjects with treatment-refractory OCD that would otherwise be candidates for ablative neurosurgery.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该研究项目的目的是减少症状严重程度，并提高严重且难以忍受的强迫症的受试者的生活质量。尽管药理和行为疗法的进展，但在常规和实验性干预措施几年后，大量患者未能显着改善。对于某些患者而言，立体定向神经外科手术是剩下的唯一有前途的选择。现有证据表明，这些程序可能会导致大多数顽固性疾病的强迫症患者的持久益处和相对较少的副作用。但是，这些消融技术对脑组织和功能的影响是不可逆的。一组欧洲研究人员使用双侧深脑刺激DB在内部囊的前肢的双侧深脑刺激DB中报告了四个棘手的OCD病例的阳性结果。在获得更广泛使用之前，合格的精神病学团队的独立确认至关重要。已经有迹象表明，全国各地的许多中心正在追求它。尽管DBS与消融性手术一样，是一种具有侵入性的手术，具有很少但严重的风险，但与消融技术不同，DBS是可调的，并且部分可逆。当前的项目旨在收集有关慢性刺激DB的有效性，安全性和耐受性通过双侧植入电极在6名受试者内部胶囊的前肢中的有效性，安全性和耐受性，否则否则将是候选消化神经外科手术的治疗性饮食性OCD。