PANCREATIC ENZYME LEVELS IN DUODENAL FLUID OF CP PATIENTS - EURAND PEP

CP 患者十二指肠液中的胰酶水平 - EURAND PEP

• 批准号: 7950745
• 负责人: Phillip TOSKES
• 金额: $ 1.15万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950745
• 关键词: Abdominal Pain; Amylases; Biological Assay; Cholecystokinin; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Duodenum; Evaluation; Excretory function; Exocrine pancreatic insufficiency; Fasting; Fatty acid glycerol esters; Feedback; Funding; Grant; Institution; Intestines; Laboratories; Lipase; Liquid substance; Malabsorption Syndromes; Methodology; Pancreas; Pancreatic enzyme; Patients; Peptide Hydrolases; Peptides; Preparation; Research; Research Personnel; Resources; Source; Techniques; United States National Institutes of Health; Upper arm; chronic pancreatitis; expectation; feeding; pancreatic juice; Abdominal Pain; Amylases; Biological Assay; Cholecystokinin; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Duodenum; Evaluation; Excretory function; Exocrine pancreatic insufficiency; Fasting; Fatty acid glycerol esters; Feedback; Funding; Grant; Institution; Intestines; Laboratories; Lipase; Liquid substance; Malabsorption Syndromes; Methodology; Pancreas; Pancreatic enzyme; Patients; Peptide Hydrolases; Peptides; Preparation; Research; Research Personnel; Resources; Source; Techniques; United States National Institutes of Health; Upper arm; chronic pancreatitis; expectation; feeding; pancreatic juice

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate expectation of this study and of the continued studies of feedback inhibition of pancreatic secretion in our laboratory is to develop a potent pancreatic enzyme preparation which can release its compounds consistently into the duodenum. Delivery of pancreatic lipase, amylase and total protease will be evaluated utilizing a intestinal aspiration methodology that this laboratory has utilized successfully on numerous occasions. Thirty subjects with chronic pancreatitis will be studied, fifteen of whom will have excretion of elevated amounts of fecal fat pancreatic insufficiency and fifteen with abdominal pain but who have not yet developed insufficiency. The delivery of lipase, amylase and total protease will be compared in a fasted and fed state with and without the addition of pancreatic enzymes. The levels of CCK and CCK releasing peptide will be collected and assayed in each arm of the study. This study will demonstrate the efficacy of the Eurand Pancreatic Enzyme Product PEP. This technique is a necessity for the evaluation of all pancreatic enzyme preparations whether it is for the treatment of fat malabsorption or abdominal pain.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的最终期望以及我们实验室中胰腺分泌反馈抑制的持续研究是开发有效的胰酶制剂，可以将其化合物始终如一地释放到十二指肠。 胰腺脂肪酶，淀粉酶和总蛋白酶的递送将通过肠道抽吸方法进行评估，该方法在许多情况下已成功使用了该实验室。 将研究30名患有慢性胰腺炎的受试者，其中15名将排泄粪便脂肪胰腺胰腺不足的含量升高，腹部疼痛有15例，但尚未出现不足。 脂肪酶，淀粉酶和总蛋白酶的递送将在有或不加入胰腺酶的情况下以禁食和喂养状态进行比较。 CCK和CCK释放肽的水平将在研究的每个部门中收集和测定。这项研究将证明欧洲胰腺酶产品PEP的功效。 该技术是评估所有胰酶制剂的必要条件，无论是用于治疗脂肪吸收不良还是腹痛。