TEDDY

泰迪熊

基本信息

批准号：
7950713
负责人：
DESMOND Arthur SCHATZ
金额：
$ 4.97万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-12-01 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7950713
关键词：
Alleles Birth Child Chronic Disease Clinical Research Colorado Computer Retrieval of Information on Scientific Projects Database Disease Environmental Exposure Environmental Risk Factor Etiology Exposure to Finland First Degree Relative Florida Funding General Population Genes Genetic Genetic Risk Germany Goals Grant Individual Institution Insulin-Dependent Diabetes Mellitus Lead Newborn Infant Pattern Predisposition Psychological Factors Psychosocial Factor Relative (related person)Research Research Personnel Resources Risk Source Sweden United States National Institutes of Health Virus Washington high risk nutrition prevent socioeconomics

Alleles Birth Child Chronic Disease Clinical Research Colorado Computer Retrieval of Information on Scientific Projects Database Disease Environmental Exposure Environmental Risk Factor Etiology Exposure to Finland First Degree Relative Florida Funding General Population Genes Genetic Genetic Risk Germany Goals Grant Individual Institution Insulin-Dependent Diabetes Mellitus Lead Newborn Infant Pattern Predisposition Psychological Factors Psychosocial Factor Relative (related person)Research Research Personnel Resources Risk Source Sweden United States National Institutes of Health Virus Washington high risk nutrition prevent socioeconomics

展开

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes mellitus (T1DM) is one of the most common and serious chronic diseases in children, particularly in the very young. The etiology of the disease remains unclear. There is a substantial genetic component to susceptibility to T1DM. High risk HLA class II alleles appears to contribute 40-45% of genetic risk and other genes have been identified as providing more modest contributions to risk. Only about 1 in 15 children in the general population with the high risk HLA alleles and one in five with a first degree relative with type 1 diabetes and with the high risk HLA will develop T1DM. Epidemiologic patterns suggest that viruses, nutrition, toxic agents or socioeconomic psychosocial factors may contribute alone or in combination. Definitive identification of environmental factors that precipitate T1DM has proven difficult. The long-term goal of this NIH-funded TEDDY study is the identification of infectious, dietary, or other environmental exposures and psychological factors which trigger or prevent T1DM in genetically susceptible individuals. We will study from birth, high-risk children from the general population and relatives of people with T1DM for exposures to candidate environmental factors. Over 200,000 newborn babies will be screened by 6 centers in the US (Florida/Georgia, Colorado, Washington state), Finland, Sweden and Germany. Identification of such factors will lead to a better understanding of the cause of T1DM and could result in new strategies to prevent, delay, or reverse T1DM.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。 1型糖尿病（T1DM）是儿童中最常见和最严重的慢性疾病之一，尤其是在年轻人中。该疾病的病因尚不清楚。对T1DM的敏感性有很大的遗传成分。高风险HLA II类等位基因似乎贡献了40-45％的遗传风险，而其他基因已被确定为为风险提供了更适度的贡献。在高风险HLA等位基因的普通人群中，只有15名儿童中只有大约1名，其中1个患有1型糖尿病和高风险HLA的第一学位亲戚将发展为T1DM。流行病学模式表明，病毒，营养，有毒药物或社会经济心理因素可能会单独或联合起来。事实证明，对沉淀T1DM的环境因素的确定识别很困难。这项NIH资助的泰迪研究的长期目标是鉴定感染性，饮食或其他环境暴露和心理因素，这些因素和心理因素触发或阻止遗传易感人群T1DM。我们将从出生中学习，来自一般人群的高风险儿童以及T1DM患者的亲戚，以暴露于候选环境因素。在美国（佛罗里达/佐治亚州，科罗拉多州，华盛顿州），芬兰，瑞典和德国的6个中心将筛选超过20万名新生婴儿。识别此类因素将使对T1DM的原因有更好的了解，并可能导致预防，延迟或反向T1DM的新策略。