ANTERIOR PITUITARY HORMONE REPLACEMENT IN TRAUMATIC BRAIN INJURY

垂体前叶激素替代治疗脑外伤

• 批准号: 7952145
• 负责人: Randall J Urban
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952145
• 关键词: Adult; Aerobic; Anterior Pituitary Hormones; Biopsy; Body Composition; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hormones; Hospitalization; Hydrocortisone; Hypopituitarism; Institution; Learning; Muscle; Muscle function; Neuropsychological Tests; Neuropsychology; Performance; Rehabilitation Research; Rehabilitation therapy; Research; Research Institute; Research Personnel; Resources; Site; Somatotropin; Source; TBI Patients; Testing; Thyroid Gland; Thyroid Hormones; Trauma; Traumatic Brain Injury; United States National Institutes of Health; growth hormone deficiency; improved; r-hGH-M

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Trauma is a well-recognized cause of hypopituitarism. Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by GH stimulation testing. Moreover, abnormalities have also been established for the cortisol and thyroid axis. The hypothesis of this proposal is that hormone replacement in TBI patients with documented abnormalities in the GH, thyroid, or cortisol axis will improve muscle function, body composition, aerobic capacity (GH) and performance in tests of neuropsychologic function (GH, thyroid, cortisol). The Aims of this study are to: 1) determine the effect of thyroid hormone replacement on neuropsychologic function in subjects with TBI, 2) determine the effect of cortisol replacement on neuropsychologic function in subjects with TBI, and 3) determine the effect of recombinant human growth hormone (rhGH) on muscle function, body composition, aerobic capacity, and neuropsychologic function in subjects with TBI. Study sites will include, the General Clinical research center at U.T.M.B. in Galveston, the Transitional Learning Center (TLC) in Galveston, and at The Institute for Research and Rehabilitation (TIRR) in Houston. Activities specifically conducted at the GCRC in Galveston will include aerobic capacity testing, strength testing, body composition analysis, and muscle biopsies on the growth hormone treatment group.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 创伤是众所周知的垂体性症状。遭受外伤性脑损伤（TBI）的成年人中有15％至20％的成年人被发现通过GH刺激测试患有生长激素（GH）缺乏症。 此外，还为皮质醇和甲状腺轴建立了异常。 该提议的假设是，在GH，甲状腺或皮质醇轴上有证明异常的TBI患者的激素替代将改善肌肉功能，身体组成，有氧运动能力（GH）和神经心理功能的测试（GH，甲状腺，甲状腺，皮质醇）。 The Aims of this study are to: 1) determine the effect of thyroid hormone replacement on neuropsychologic function in subjects with TBI, 2) determine the effect of cortisol replacement on neuropsychologic function in subjects with TBI, and 3) determine the effect of recombinant human growth hormone (rhGH) on muscle function, body composition, aerobic capacity, and neuropsychologic function in subjects with TBI。研究地点将包括U.T.M.B.的一般临床研究中心在加尔维斯顿，加尔维斯顿的过渡学习中心（TLC）以及休斯敦的研究与康复研究所（TIRR）。在加尔维斯顿的GCRC上专门进行的活动将包括有氧能力测试，强度测试，身体成分分析以及生长激素治疗组上的肌肉活检。