BMC--BHASIN

基本信息

批准号：
7877926
负责人：
SHALENDER BHASIN
金额：
$ 77.35万
依托单位：
BOSTON MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7877926
关键词：
Age Aging American Biological Markers Biological Models Biology Boston Caloric Restriction Centenarian Clinic Clinical Clinical Research Collaborations Communities Community Outreach Computer Assisted Core Facility Dependence Development Discipline Education Elderly Endocrinology Epidemiologic Studies Epidemiology Event Exercise Exercise Physiology Fostering Fracture Framingham Heart Study Funding Generations Geriatrics Gerontology Grooming Health Services Human Individual Interdisciplinary Study Intervention Trial K-Series Research Career Programs Leadership Life Link Massachusetts Medical center Mentors Methods Modality Molecular Genetics Monitor Muscle New England Newsletter Nutritional Outcome Outcome Assessment Outcome Measure Physical Function Physical activity Pilot Projects Positioning Attribute Prevention Process Quality of life Recording of previous events Recruitment Activity Research Research Activity Research Infrastructure Research Personnel Research Training Resources Risk Scientist Signal Transduction Stem cells Structure Systems Biology Technology Testosterone Training Training Programs Translational Research Translations Universities Validation age related base bench to bedside career development cohort cost disability drug discovery efficacy trial evidence base experience falls functional decline improved innovation instrument interdisciplinary approach interdisciplinary collaboration male meetings member method development mortality next generation novel nutrition older men pre-clinical programs tool translational approach web site

项目摘要

Boston Medical Center, Boston, Massachusetts (BMC) Bhasin, Shalender Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers.

马萨诸塞州波士顿波士顿医疗中心（BMC） Bhasin，Shalender 老年人的功能下降和依赖性预示了不良结果，并施加了巨大的负担关于医疗保健服务和费用。因此，促进改进的合成代谢疗法（FPAT）的功能身体功能并减少禁用功能限制的负担。波士顿克劳德 A.辣椒年龄较大的美国人独立中心（OAIC），其主题关注功能限制和 FPAT将将13项NIH资助的研究，4个创新的试点项目和2个发展项目整合到一个由领导力和行政核心支持的凝聚力跨学科计划，一项研究职业发展核心（RCDC），一项飞行员和探索性研究，以及三个资源核心（功能评估核心，肌肉祖细胞核心和系统生物学核心）。波士顿的欧洲裔是在整个转化发现研究中的位置独特飞行员和发展项目将阐明功能限制和 FPAT作用的机制，有助于确定FPAT发现的目标和FPAT动作的生物标志物，以及促进领先FPAT的方法开发，结果验证和功效试验。 RCDC将从几个学科中招募最佳候选人，指示老年医学和老年学，并训练它们通过结构化教育和指导研究计划。 OAIC的整合将是通过每周跨学科研究会议，双年度务虚会，网站，常见主题实现重点和旨在促进合作的促进计划。社区宣传和将通过大使的计划来实现OAIC活动的传播社区活动，新闻通讯和社区顾问委员会。 OAIC的独特优势包括专注于FPAT，强调创新，其在整个转化研究中的扩展阐明有效试验的机制，其成员之间有效合作的历史基础设施和机构承诺，并包括一些重要的流行病学研究（FHS，MMA，BACH，百年研究和BOKS），FPAT干预试验以及基于机制的FPAT 发现。波士顿OALC的协作策略应有助于加快研究结果的翻译进入基于证据的FPAT并培养新一代的老龄化研究人员。