UCLA Center for AIDS Research (CFAR)

加州大学洛杉矶分校艾滋病研究中心 (CFAR)

• 批准号: 7619519
• 负责人: Jerome A. Zack
• 金额: $ 251.63万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7619519
• 关键词: UCLA; Center; AIDS; Research; CFAR

DESCRIPTION (provided by applicant): This application constitutes a renewal on the part of the University of California/Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its seven affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage a faculty that has grown by 30% in the last five years and CFAR-applicable grants that have risen by 50% since we submitted our last renewal application. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross-disciplinary collaborations. The UCLA CFAR consists of more than 200 faculty investigators who are responsible for more than 250 research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative research projects. The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short- and long-term goals, two cores were eliminated and a Clinical Research Facilitation Core and a Consultation Core are added. CORE A: Administrative Core (Zack, J.) CORE A DESCRIPTION (provided by applicant): The Administrative Core of the UCLA CFAR will provide infrastructure support that adds value to all AIDS-related research and programs at UCLA. The Administrative Core is responsible for overseeing all operational and governance aspects of the UCLA CFAR. The joint administration of the UCLA CFAR and the AIDS Institute provides the following forms of support for the CFAR: fiscal administration and grants management, procurement of equipment and supplies, short- and long-range planning, administrative support for CFAR symposia, colloquia, and think tanks (including financial, editorial, graphic-design, and logistical support), development of educational programs for scientists and laypersons, on-campus and community-based outreach activities, administrative support for seed grant and fellowship reviews, compliance with all UCLA, University of California and NIH requirements, marketing and fund-raising, respond to requests for information and assistance (from the NIH, from our colleagues and collaborators, from the press and public), and supervision of all of the day-to-day activities of the CFAR. The Administrative Core will provide efficient, effective management of all CFAR programs through an accessible, streamlined and responsive administrative operation. The Administrative Core is overseen jointly by the Principal Investigator of the CFAR, Dr. Jerome Zack, and the Co-Pi of the CFAR, Dr. In/in Chen, who is also the Director of the UCLA AIDS Institute. The specific aims of this Core are: Aim 1. Program Development: Develop, implement and coordinate programs that support the wide-ranging research activities of the UCLA CFAR through a flexible and responsive administrative structure designed to maximize access to information and assistance, to enhance communication and to encourage collaboration. Aim 2. New Investigator Development: Facilitate the work of all UCLA AIDS researchers, but particularly junior, new and minority investigators, through specific mechanisms, such as mentorship programs and assistance with IRB applications, human-subject recruitment, data analysis, and grant writing, that reduce time, costs, and effort. Aim 3. Business Affairs Administration: To provide an infrastructure dedicated to AIDS research through funding of administrative services and overall coordination of research activities, think tanks, seed grant reviews and other activities of the CFAR.

描述（由申请人提供）：本申请构成了加利福尼亚大学/洛杉矶分校（UCLA）的续期，用于艾滋病研究中心（CFAR）赠款。该赠款将资助UCLA CFAR在UCLA AIDS研究所内部进行的活动和计划。 UCLA CFAR成立于1988年，艾滋病研究所成立于1992年，旨在协调该大学及其在一个中央政府领导下的七家附属教学医院的艾滋病研究，临床和教育活动。艾滋病研究所和CFAR的整体组织在2005年进行了重组，以更加有效地管理一个教职员工，该教师在过去五年中增长了30％，自从我们提交了最后一次续签申请以来，该教师已增长了50％。此续签应用包括CFAR核心服务和活动，旨在通过基本，临床和行为科学来促进艾滋病毒/艾滋病知识。 UCLA CFAR的总体使命是在各种学科之间创造协同作用，从而在理解，预防和治疗艾滋病毒感染方面取得了重大突破，并特别强调高价值的跨学科合作。 UCLA CFAR由200多名教职员工组成，他们负责250多个研究项目，这些研究项目实际上涵盖了艾滋病毒/艾滋病生物学，临床研究和行为科学的各个方面。加州大学洛杉矶分校（UCLA）一直在艾滋病研究，教育，教学以及临床计划方面的卓越卓越机构中排名最高的机构。洛杉矶大都会是艾滋病流行病的主要中心，也是美国最多样化的地区之一，我们的计划旨在与这些不同的社区接触。我们特别自豪的是，近年来，有50％的患者进入我们的临床试验是少数民族社区的成员。 CFAR的作用是通过支持科学和行政核心设施来促进大学内外的合作和建立联系，并为高度优异的合作研究项目提供种子赠款资金。 The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core.基于变化的流行病学，需求评估，战略计划以及修订后的短期目标，消除了两个核心，并增加了临床研究促进核心和咨询核心。 核心A：行政核心（Zack，J。） 核心描述（由申请人提供）：UCLA CFAR的管理核心将提供基础架构支持，为UCLA的所有与AIDS相关的研究和计划增加价值。行政核心负责监督UCLA CFAR的所有运营和治理方面。 The joint administration of the UCLA CFAR and the AIDS Institute provides the following forms of support for the CFAR: fiscal administration and grants management, procurement of equipment and supplies, short- and long-range planning, administrative support for CFAR symposia, colloquia, and think tanks (including financial, editorial, graphic-design, and logistical support), development of educational programs for scientists and laypersons, on-campus and community-based outreach活动，对种子赠款和奖学金审查的行政支持，对加州大学所有加州大学洛杉矶分校，加利福尼亚大学以及NIH要求的遵守，营销和筹款，响应信息和帮助的请求（来自NIH，来自我们的同事和合作者，来自新闻和公众的），以及对Cfar所有日常活动的监督。行政核心将通过可访问，简化和响应迅速的管理操作来提供所有CFAR计划的有效管理。行政核心由CFAR的首席研究员Jerome Zack博士和CFAR的CO-PI共同监督，CFAR博士In/In Chen也是UCLA AIDS Institute的主任。该核心的具体目的是：目标1。计划开发：开发，实施和协调计划，通过灵活且响应迅速的行政结构来支持UCLA CFAR的广泛研究活动，旨在最大程度地提高信息和帮助的访问，以增强沟通并鼓励协作。目标2。新的研究者开发：通过特定机制，例如指导计划以及对IRB应用程序的帮助，人为受试者招聘，数据分析和授予写作，促进所有UCLA AIDS研究人员的工作，尤其是初级，新和少数派研究人员，从而减少时间，成本和精力。目标3。商业事务管理局：通过资助行政服务以及研究活动，智囊团，种子赠款评论和CFAR的其他活动，提供致力于艾滋病研究的基础设施。