UCLA OLDER AMERICANS INDEPENDENCE CENTER

加州大学洛杉矶分校美国老年人独立中心

• 批准号: 7643175
• 负责人: DAVID B. REUBEN
• 金额: $ 108.92万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7643175
• 关键词: UCLA; OLDER; AMERICANS; INDEPENDENCE; CENTER

DESCRIPTION (provided by applicant): Established in 1991, the UCLA Claude D. Pepper Older Americans Independence Center (UCLA OAIC) seeks a third renewal to continue its mission of expanding the scientific knowledge that will lead to better ways to maintain or restore independence. In this renewal, we will focus our efforts on the theme, "Developing Interventions to Maintain Independence and Understanding Mechanisms of Successful Interventions," which extends the Center's prior research. Thus, the emphasis will be on research that builds bridges between basic biomedical science and clinical science. In the UCLA OAIC paradigm, basic biomedical research informs clinical research and clinical research informs basic biomedical research. Accordingly, the UCLA OAIC will support research that links these two types of research in both directions by 1) examining mechanisms underlying successful clinical interventions and 2) developing new basic science approaches that will lead to clinical interventions. The Center will stimulate scientific discovery through 4 Research Cores (Recruitment, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies (P/EC) Core, and Research Career Development Core (RCDC). Research Cores will provide 4 levels of support (consultation, short-term, ongoing, and partnership on new projects) for external projects (e.g., R01s) and internal OAIC activities (e.g., pilots and Career Development Awardees). The UCLA OAIC will accomplish its goals by accomplishing 6 Specific Aims: 1) To provide intellectual leadership and innovation for geriatrics and aging research on the Center's theme and related research 2) To stimulate translational links between basic and clinical research, with an emphasis on inflammation 3) To facilitate and develop novel multidisciplinary research 4) To stimulate incorporation of emerging technologies 5) To serve as source of advice and collaboration to other institutions 6) To provide career development of future research leaders.

描述（由申请人提供）：成立于1991年，UCLA Claude D. Peper D. Peper老年人独立中心（UCLA OAIC）寻求第三个更新，以继续其使命，以扩大科学知识，从而导致维持或恢复独立性的更好方法。 在这种续约中，我们将重点放在主题上，即“制定干预措施，以保持独立性和理解成功干预措施的机制”，这扩展了中心的先前研究。 因此，将重点放在建立基本生物医学科学与临床科学之间的桥梁的研究上。在UCLA OAIC范式中，基本的生物医学研究为临床研究和临床研究提供了信息。因此，UCLA OAIC将支持将这两种类型的研究在这两个方向上通过1）进行研究的研究。1）检查成功的临床干预措施的基础机制； 2）开发新的基础科学方法，这些方法将导致临床干预。 该中心将通过4个研究核心（招聘，研究操作，分析和成本效益以及炎症生物学），试点和探索性研究（P/EC）核心以及研究职业发展核心（RCDC）刺激科学发现。研究核心将为外部项目（例如R01S）和内部OAIC活动（例如，飞行员和职业发展获奖者）提供4个级别的支持（咨询，短期，持续和伙伴关系）。 UCLA OAIC将通过实现6个具体目标来实现其目标：1）为中心的主题和相关研究提供有关老年医学和衰老研究的智力领导和创新，以刺激基础研究和临床研究之间的翻译联系，并强调炎症3），以促进和开发新型多学科研究，以促进和发展新型多学科研究。机构6）提供未来研究领导者的职业发展。