Enhancing HIV Secondary Prevention in a clinical care setting in southern India

加强印度南部临床护理环境中的艾滋病毒二级预防

• 批准号: 7686797
• 负责人: Kartik Kailas Venkatesh
• 金额: $ 4.85万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-26 至 2012-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7686797
• 关键词: AIDS prevention; AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Address; Adherence; Adult; Affect; Anti-Retroviral Agents; Attenuated; Behavior; Behavior Therapy; Behavioral; Belief; Businesses; Caring; Castes; Cessation of life; Characteristics; Clinical; Cognitive; Coitus; Communities; Complex; Counseling; Coupled; Couples; Data; Development; Drops; Education; Ensure; Epidemic; Ethnography; Future; Gender; Goals; HIV; Heterosexuals; Highly Active Antiretroviral Therapy; Husband; India; Individual; Intervention; Lead; Life; Linguistics; Measures; Mediation; Medical; Modeling; Motivation; Participant; Patients; Pattern; Persons; Pharmaceutical Preparations; Play; Population; Population Dynamics; Prevention; Prevention strategy; Preventive Intervention; Primary Health Care; Primary Prevention; Professional counselor; Public Health; Recommendation; Relative (related person); Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Risk-Taking; Role; Route; Secondary Prevention; Sex Behavior; Sexual Partners; Staging; Structure; Testing; Travel; United States; Variant; Virus; Wife; Woman; Work; antiretroviral therapy; base; behavior change; clinical care; cost; experience; flexibility; high risk; high risk behavior; men; prevent; psychosocial; segregation; sex; sex risk; skills training; social; success; transmission process; treatment program; working men

DESCRIPTION (provided by applicant): This is a proposal to understand the behavioral consequences of increased access to anti-retroviral therapy (ART) among HIV infected married men in South India and to do formative studies, which will ultimately lead to developing a behavioral intervention to promote secondary prevention. The proposed research will first involve conducting quantitative and ethnographic research to understand unsafe sexual practices among HIV-infected married men in Chennai, South India. Currently India has over 5 million individuals with HIV/AIDS. With the advent of highly active anti-retroviral therapy (HAART) in the developed world, deaths related to HIV have dropped and the number of patients living with HIV has continued to increase. As HIV treatment increasingly becomes available and accessible in India, risk reduction may appear less necessary among people with HIV. The future reduction of HIV transmission in India will require new strategies that emphasize prevention of transmission by HIV-infected persons. This study will lead to recommendations for incorporating HIV behavioral preventions into the medical care of HIV infected individuals in India. The proposed study will access behavioral modules based on a secondary prevention intervention for high risk HIV populations in the United States that can be selectively applied to an Indian setting. It is hoped that the development of a culturally-sensitive behavioral intervention coupled with antiretroviral treatment among HIV infected individuals will decrease the spread of the HIV epidemic. The first aim will identify predicators of sexual risk among HIV infected married men who are currently undergoing antiretroviral therapy and who are not undergoing antiretroviral therapy cross-sectionally. The study will then determine psychosocial, behavioral, and biomedical variations among HIV infected married men and assess whether to focus a secondary prevention intervention on specific characteristics. Additional data will be collected as necessary for developing a secondary behavioral intervention integrated into HIV treatment to reduce unsafe sexual behavior among HIV infected married men tailored to an Indian sociocultural setting. The relevance to public health will involve examining the possibilities of integrating secondary prevention into routine HIV community treatment settings. This study will explore the current availability of HIV prevention strategies, such as voluntary counseling and testing (VCT), and access which aspects may be relevant as part of culturally relevant secondary risk reduction strategies in India. This study will assess the cultural relevance and feasibility of implementing a counseling condition based on models addressing information, motivation to change, and behavioral skills training for an Indian social and clinical setting.

描述（由申请人提供）：这是一项建议，旨在了解在印度南部感染了艾滋病毒感染的已婚男性并进行形成性研究的抗逆转录病毒疗法（ART）的行为后果，这最终将导致行为干预以促进二级预防。拟议的研究将首先涉及进行定量和民族志研究，以了解印度南部钦奈的HIV感染已婚男子之间不安全的性行为。目前，印度拥有超过500万艾滋病毒/艾滋病的人。随着发达国家高度活跃的抗逆转录病毒疗法（HAART）的出现，与艾滋病毒有关的死亡人数下降了，艾滋病毒感染患者的数量继续增加。随着艾滋病毒治疗越来越多地在印度获得，在艾滋病毒患者中，降低风险的可能性可能较小。印度艾滋病毒传播的未来减少将需要新的策略，以强调预防受艾滋病毒感染者的传播。这项研究将导致建议将HIV行为预防纳入印度艾滋病毒感染者的医疗保健。拟议的研究将基于美国高风险艾滋病毒人群的二级预防干预措施访问行为模块，可以选择性地应用于印度环境。希望在艾滋病毒感染的个体中，对文化敏感的行为干预以及抗逆转录病毒治疗的发展将减少HIV流行的传播。第一个目的将确定目前正在接受抗逆转录病毒疗法并且没有在横截面上进行抗逆转录病毒疗法的艾滋病毒感染的已婚男性的性风险鉴定。然后，该研究将确定艾滋病毒感染已婚男性的社会心理，行为和生物医学变异，并评估是否将二级预防干预集中在特定特征上。将根据需要在艾滋病毒治疗中纳入二次行为干预措施，以减少针对印度社会文化环境量身定制的艾滋病毒感染的已婚男人的不安全性行为，以减少二级行为干预措施，从而收集其他数据。与公共卫生的相关性将涉及研究将二级预防纳入常规艾滋病毒社区治疗环境的可能性。这项研究将探讨当前预防艾滋病毒预防策略的可用性，例如自愿咨询和测试（VCT），以及在印度与文化相关的二级风险降低策略的一部分可能相关的方面。这项研究将评估基于涉及信息，改变动机以及为印度社会和临床环境的模型，实施咨询条件的文化相关性和可行性。